ArticleMolecular biology reports2010
Molecular cloning of liver Wap65 cDNA in ayu (Plecoglossus altivelis) and mRNA expression changes following Listonella anguillarum infection.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 30 citations in OpenAlex.
- Transcriptomic Insights into Post-Spawning Death and Muscle Atrophy in Ayu (International journal of molecular sciences · 2025Article
- Innate immune and chronic heat stress responses in sturgeons: Advances and insights from studies on Russian sturgeons.Fish and shellfish immunology reports · 2023Article
- Serum amyloid A is a positive acute phase protein in Russian sturgeon challenged with Aeromonas hydrophila.Scientific reports · 2020Article
- Characterization of carp seminal plasma Wap65-2 and its participation in the testicular immune response and temperature acclimation.Veterinary research · 2020Article
- Impact of three commercial feed formulations on farmed gilthead sea bream (Sparus aurata, L.) metabolism as inferred from liver and blood serum proteomics.Proteome science · 2014Article
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4 authors at 1 institution in 1 country.
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Abstract
The teleost warm temperature acclimation related 65 kDa protein (Wap65) is a plasma glycoprotein with the potential roles in heat adaptation, heme recycling, immune response and copper metabolism. It is most homologous to the mammalian hemopexin, which is the plasma transporter of heme. A full-length cDNA clone of the Wap65 gene, 1,534 bp in size, was isolated from the fish ayu (Plecoglossus altivelis). Its deduced amino acid sequence of 439 residues had 60.4-65.4% and 38.3-47.3% identical to fish Wap65-2-type and Wap65-1-type sequences, respectively. In phylogenetic analysis, aWap65 grouped tightly with those fish Wap65-2-type sequences. In healthy control fish, the highest mRNA signal for aWap65 was from the liver, moderately high in brain and gill, and but weaker in spleen, kidney, muscle, heart and intestine. In Listonella anguillarum-infected fish, aWap65 transcripts were significantly increased in liver, while no obvious changes in other tissues at 12 hpi. However, aWap65 transcripts were significantly increased in various tissues at 24 hpi when hemolysis developing, suggesting that aWap65 might be involved in the immune response of ayu.
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