ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2009
Evidence for the contribution of tumour necrosis factor in oedema formation induced by histamine in the hind paw of the rat.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- The Effect ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Crocin alleviates the local paw edema induced by histamine in rats.Avicenna journal of phytomedicine · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
There is mounting evidence that tumour necrosis factor (TNF) is involved in the early phase of inflammatory response, but its relation to histamine action is unclear. In this study we examined the effect of drugs interfering with TNF expression (thalidomide) and activity (infliximab) and compared it to that of a H(1)R histamine receptor antagonist (loratadine) in a model of histamine-induced rat hind-paw oedema formation. Systemic administration of all three drugs effectively reduced the oedema formed by the subsequent transplantar administration of histamine into the rat paw, in a dose-dependent manner. The time-dependence of the effect exerted by thalidomide and infliximab was very similar to that of loratadine. Moreover, there appears no significant synergistic effect between infliximab and loratadine, suggesting that TNF is either a major modulator or a direct mediator of oedema formation induced by histamine, in the rat paw.
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