ArticleJournal of neurology2009
Outcome in subgroups of mild cognitive impairment (MCI) is highly predictable using a simple algorithm.
Article in Journal of neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuropsychological Measures that Predict Progression from Mild Cognitive Impairment to Alzheimer's type dementia in Older Adults: a Systematic Review and Meta-Analysis.Neuropsychology review · 2017Pooled it
- Low-dose ladostigil for mild cognitive impairment: A phase 2 placebo-controlled clinical trial.Neurology · 2019Trial
- Trial
- Microbiota-Gut-Brain Axis Mechanisms in Cognitive Impairment Associated with Central Obesity.Current obesity reports · 2026Review
- Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry.Alzheimer's research & therapy · 2025Article
- A passive and objective measure of recognition memory in mild cognitive impairment using Fastball memory assessment.Brain communications · 2025Article
- Modifiable dementia risk associated with smaller white matter volume and altered 1/f aperiodic brain activity: cross-sectional insights from the LEISURE study.Age and ageing · 2024Article
- Article
- Unsupervised Online Paired Associates Learning Task from the Cambridge Neuropsychological Test Automated Battery (CANTAB®) in the Brain Health Registry.The journal of prevention of Alzheimer's disease · 2024Article
- Computerized paired associate learning performance and imaging biomarkers in older adults without dementia.Brain imaging and behavior · 2022Article
- Abnormal Functional Hierarchies of EEG Networks in Familial and Sporadic Prodromal Alzheimer's Disease During Visual Short-Term Memory Binding.Frontiers in neuroimaging · 2022Article
- Brain atrophy pattern in patients with mild cognitive impairment: MRI study.Translational neuroscience · 2022Article
- Cerebral microemboli in mini-sternotomy compared to mini- thoracotomy for aortic valve replacement: a cross sectional cohort study.Journal of cardiothoracic surgery · 2021Observational
- Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus).Scientific reports · 2021Article
- Reduced cognitive ability in people with rheumatoid arthritis compared with age-matched healthy controls.Rheumatology advances in practice · 2021Article
- A multivariate model of time to conversion from mild cognitive impairment to Alzheimer's disease.GeroScience · 2020Article
- Comparison of Amyloid Positivity Rate and Accumulation Pattern between Amnestic and Non-Amnestic Type Mild Cognitive Impairment.Psychiatry investigation · 2020Article
- Electroencephalographic Cross-Frequency Coupling as a Sign of Disease Progression in Patients With Mild Cognitive Impairment: A Pilot Study.Frontiers in neuroscience · 2020Article
- The Consortium for the early identification of Alzheimer's disease-Quebec (CIMA-Q).Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- A highly predictive signature of cognition and brain atrophy for progression to Alzheimer's dementia.GigaScience · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Although it is well recognized that MCI represents a risk state for subsequent dementia, estimates of conversion vary widely according to the diagnostic criteria employed. There are currently no simple cognitive predictors of high and low risk of progression. We followed 107 non-demented non-depressed subjects from an original cohort of 124--sub-classified as follows: pure amnestic MCI (22), multi-domain MCI (54), non-amnestic MCI (10) and worried well (21). At 2 years, outcome varied considerably. Of the multi-domain MCI group 59% progressed to dementia and only 5% improved. By contrast, in pure amnestic MCI only 18% progressed and 41% improved. Of non-amnestic MCI patients 70% improved. The best predictor of progression was a combination of the Addenbrooke's cognitive examination (ACE) and the paired associate learning task (PAL), which produced high negative predictive (90%) and sensitivity (94%) values. The results indicate very different outcomes according to whether patients have pure amnestic versus multi-domain MCI. While the latter is an aggressive disorder, the former is more benign and unstable even in a clinic setting. Patients with scores >88 on the ACE and/or <14 errors on the PAL can be confidently reassured of a good prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.