ReviewNature reviews. Genetics2009
Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling.
Review in Nature reviews. Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed.
- Article
- Advances in experimental bladder models: bridging the gap between in vitro and in vivo approaches for investigating urinary tract infections.BMC urology · 2024Review
- Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- Human INHBB Gene Variant (c.1079T>C:p.Met360Thr) Alters Testis Germ Cell Content, but Does Not Impact Fertility in Mice.Endocrinology · 2022Article
- Zebrafish and Flavonoids: Adjuvants against Obesity.Molecules (Basel, Switzerland) · 2021Review
- Enviromics in breeding: applications and perspectives on envirotypic-assisted selection.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Reply to 'It is time for an empirically informed paradigm shift in animal research'.Nature reviews. Neuroscience · 2020Article
- High-throughput discovery of genetic determinants of circadian misalignment.PLoS genetics · 2020Article
- Digital envirotyping: quantifying environmental determinants of health and behavior.NPJ digital medicine · 2020Article
- The anatomy of phenotype ontologies: principles, properties and applications.Briefings in bioinformatics · 2018Article
- Ontology-based validation and identification of regulatory phenotypes.Bioinformatics (Oxford, England) · 2018Article
- Epigenetics as a mechanism linking developmental exposures to long-term toxicity.Environment international · 2018Review
- Reproducibility and replicability of rodent phenotyping in preclinical studies.Neuroscience and biobehavioral reviews · 2018Review
- Animal models of obesity and diabetes mellitus.Nature reviews. Endocrinology · 2018Review
- Each pregnancy linearly changes immune gene expression in the blood of healthy women compared with breast cancer patients.Clinical epidemiology · 2018Article
- Update of neurotrophic factors in neurobiology of addiction and future directions.Neurobiology of disease · 2017Review
- Translational Rodent Models for Research on Parasitic Protozoa-A Review of Confounders and Possibilities.Frontiers in cellular and infection microbiology · 2017Review
- INFRAFRONTIER: a European resource for studying the functional basis of human disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography.Biomedical optics express · 2016Article
- Epigenetic germline inheritance of diet-induced obesity and insulin resistance.Nature genetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse is the leading mammalian model organism for basic genetic research and for studying human diseases. Coordinated international projects are currently in progress to generate a comprehensive map of mouse gene functions - the first for any mammalian genome. There are still many challenges ahead to maximize the value of the mouse as a model, particularly for human disease. These involve generating mice that are better models of human diseases at the genotypic level, systemic (assessing all organ systems) and systematic (analysing all mouse lines) phenotyping of existing and new mouse mutant resources, and assessing the effects of the environment on phenotypes.
Indexed as
Identifiers
19434078What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.