ArticleJournal of applied genetics2009
Sequence variants of chemokine receptor genes and susceptibility to HIV-1 infection.
Article in Journal of applied genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- The Influence BetweenAIDS research and human retroviruses · 2023Review
- CCR2 polymorphism and HIV: mutation in both mother and child is associated with higher transmission.International journal of biochemistry and molecular biology · 2019Article
- Possible Impact of 190G > A CCR2 and Δ32 CCR5 Mutations on Decrease of the HBV Vaccine Immunogenicity-A Preliminary Report.International journal of environmental research and public health · 2017Article
- The temporal increase in HIV-1 non-R5 tropism frequency among newly diagnosed patients from northern Poland is associated with clustered transmissions.Journal of the International AIDS Society · 2015Article
- Frequency of CCR5Δ32 allele in healthy Bosniak population.Bosnian journal of basic medical sciences · 2014Article
- Impact of CCR2 and SDF1 polymorphisms on disease progression in HIV-infected subjects in Thailand.Journal of clinical laboratory analysis · 2013Article
- Risk of HIV Infection and Lethality Are Decreased in CCR5del32 Heterozygotes: Focus Nosocomial Infection Study and Meta-analysis.Acta naturae · 2012Article
- Polymorphisms in chemokine and receptor genes and gastric cancer risk and survival in a high risk Polish population.Scandinavian journal of gastroenterology · 2011Article
- Risk of all-cause mortality in HIV infected patients is associated with clinical, immunologic predictors and the CCR5 Δ32 deletion.PloS one · 2011Article
- Formal reasoning on qualitative models of coinfection of HIV and Tuberculosis and HAART therapy.BMC bioinformatics · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic susceptibility to HIV infection was previously proven to be influenced by some chemokine receptor polymorphisms clustering on chromosome 3p21. Here the influence of 5 genetic variants was studied: Delta32 CCR5, G(-2459)A CCR5, G190A CCR2, G744A CX3CR1 and C838T CX3CR1. They were screened in a cohort of 168 HIV-1 positive adults [HIV(+) group] and 151 newborns [control group] from northwestern Poland. PCR-RFLP was performed to screen for the variants (except for Delta32 CCR5 polymorphism, where PCR fragment size was sufficient to identify the alleles) and then electrophoresed on agarose gel to determine fragment size. Distribution of genotypes and alleles was not significantly different between the groups except for the CCR5 polymorphisms, with the Delta32 allele and the (-2459)A CCR5 allele more frequent among neonates than in the HIV(+) group. No Delta32/Delta32 homozygotes were found in the HIV(+) group, but 16.1 percent were Delta32/wt heterozygotes. In the control group, 1.3 percent; were Delta32/Delta32 homozygotes and 26.0percent were Delta32/wt heterozygotes. Linkage between the chemokine polymorphisms was calculated using the most informative loci for haplotype reconstruction. Haplotypes containing Delta32 CCR5, 190G CCR2 and 744A CX3CR1 were found to be significantly more common in the control group. This suggests an association between these haplotypes and resistance to HIV-1 infection.
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