ArticleProceedings of the National Academy of Sciences of the United States of America2009
Location of chloride and its possible functions in oxygen-evolving photosystem II revealed by X-ray crystallography.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 234 citations in OpenAlex.
- Interrelated Roles of Chloride and Bicarbonate in Regulating Electron Transport Across Photosystem II inPlants (Basel, Switzerland) · 2026Article
- Humic Acid Modulates Photosynthetic Responses to PEG-Induced Drought inPlants (Basel, Switzerland) · 2026Article
- Chloride dependence of photosystem II operation in the hypercarbonate-requiring cyanobacterium Limnospira maxima.Photosynthesis research · 2026Article
- Photosystem II: commonality and diversity with emphasis on the extrinsic subunits.Plant & cell physiology · 2025Review
- Genome-Wide Identification and Functional Divergence of the Chloride Channel (CLC) Gene Family in Autotetraploid Alfalfa (International journal of molecular sciences · 2025Article
- Low-concentration NaCl foliar spraying enhances photosynthesis, mineral concentration, and fruit quality of strawberry during greenhouse high-temperature periods.BMC plant biology · 2025Article
- Chlorine Modulates Photosynthetic Efficiency, Chlorophyll Fluorescence in Tomato Leaves, and Carbohydrate Allocation in Developing Fruits.International journal of molecular sciences · 2025Article
- Chloride transport and homeostasis in plants.Quantitative plant biology · 2025Review
- Transcriptomic profiling of near-isogenic lines reveals candidate genes for a significant locus conferring metribuzin resistance in wheat.BMC plant biology · 2023Article
- Sensitivity of the Photosynthetic Apparatus in Maize and Sorghum under Different Drought Levels.Plants (Basel, Switzerland) · 2023Article
- Impact of Salinity on the Energy Transfer between Pigment-Protein Complexes in Photosynthetic Apparatus, Functions of the Oxygen-Evolving Complex and Photochemical Activities of Photosystem II and Photosystem I in TwoInternational journal of molecular sciences · 2023Article
- Structure of native photosystem II assembly intermediate fromFrontiers in plant science · 2023Article
- Similar Responses of Relatively Salt-Tolerant Plants to Na and K during Chloride Salinity: Comparison of Growth, Water Content and Ion Accumulation.Life (Basel, Switzerland) · 2022Article
- The Investigation of the Impact of Toxicity of Metals on Oxygen-Evolving Complex inAntioxidants (Basel, Switzerland) · 2022Article
- Binding and functions of the two chloride ions in the oxygen-evolving center of photosystem II.Photosynthesis research · 2022Review
- D139N mutation of PsbP enhances the oxygen-evolving activity of photosystem II through stabilized binding of a chloride ion.PNAS nexus · 2022Article
- Photosystem 2 and the oxygen evolving complex: a brief overview.Photosynthesis research · 2022Review
- Silicate Inhibits the Cytosolic Influx of Chloride in Protoplasts of Wheat and Affects the Chloride Transporters,Plants (Basel, Switzerland) · 2022Article
- Effective binding of TbJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021Article
- Census of halide-binding sites in protein structures.Bioinformatics (Oxford, England) · 2020Article
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4 authors at 2 institutions in 1 country.
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Abstract
The chloride ion, Cl(-), is an essential cofactor for oxygen evolution of photosystem II (PSII) and is closely associated with the Mn(4)Ca cluster. Its detailed location and function have not been identified, however. We substituted Cl(-) with a bromide ion (Br(-)) or an iodide ion (I(-)) in PSII and analyzed the crystal structures of PSII with Br(-) and I(-) substitutions. Substitution of Cl(-) with Br(-) did not inhibit oxygen evolution, whereas substitution of Cl(-) with I(-) completely inhibited oxygen evolution, indicating the efficient replacement of Cl(-) by I(-). PSII with Br(-) and I(-) substitutions were crystallized, and their structures were analyzed. The results showed that there are 2 anion-binding sites in each PSII monomer; they are located on 2 sides of the Mn(4)Ca cluster at equal distances from the metal cluster. Anion-binding site 1 is close to the main chain of D1-Glu-333, and site 2 is close to the main chain of CP43-Glu-354; these 2 residues are coordinated directly with the Mn(4)Ca cluster. In addition, site 1 is located in the entrance of a proton exit channel. These results indicate that these 2 Cl(-) anions are required to maintain the coordination structure of the Mn(4)Ca cluster as well as the proposed proton channel, thereby keeping the oxygen-evolving complex fully active.
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