ArticleNeurology2009
Who will participate in acute stroke trials?
Article in Neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Evaluating Age, Sex, Racial, and Ethnic Representation in Acute Ischemic Stroke Trials, 2010 to 2020: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2022Pooled it
- Pooled it
- Effect of waivers of consent on recruitment in acute stroke trials: A systematic review.Neurology · 2016Pooled it
- Public Acceptance of Emergency Research Without Prior Consent in Stroke.JAMA network open · 2026Article
- Proxy decision-making about participation in palliative care research: A scoping review.Palliative medicine · 2026Article
- Public support for and concerns regarding pediatric dose optimization for seizures in emergency medical services: An exception from informed consent (EFIC) trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2024Article
- Understanding factors contributing to participant satisfaction in stroke walking recovery clinical trials.Contemporary clinical trials communications · 2022Article
- Identifying Enablers of Participant Engagement in Clinical Trials of Consumer Health Technologies: Qualitative Study of Influenza Home Testing.Journal of medical Internet research · 2021Article
- Article
- Article
- Factors affecting patient participation in clinical trials in Ireland: A narrative review.Contemporary clinical trials communications · 2016Article
- Development of a Questionnaire to Investigate Study Design Factors Influencing Participation in Gait Rehabilitation Research by People with Stroke: A Brief Report.Physiotherapy Canada. Physiotherapie Canada · 2015Article
- Which factors influence the resort to surrogate consent in stroke trials, and what are the patient outcomes in this context?BMC medical ethics · 2015Article
- Automated real-time text messaging as a means for rapidly identifying acute stroke patients for clinical trials.Trials · 2014Article
- Article
- The accuracy of surrogate decision makers: informed consent in hypothetical acute stroke scenarios.BMC emergency medicine · 2013Article
- Recruitment of black subjects for a natural history study of intracerebral hemorrhage.Journal of health care for the poor and underserved · 2013Article
- Exception from informed consent for emergency research: consulting the trauma community.The journal of trauma and acute care surgery · 2013Article
- Informed consent: the rate-limiting step in acute stroke trials.Frontiers in neurology · 2011Article
- Community attitudes towards emergency research and exception from informed consent.Resuscitation · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the high incidence of acute stroke, only a minority of patients are enrolled in acute stroke treatment trials. We aimed to identify factors associated with participation in clinical trials of novel therapeutic agents for acute stroke.
methodsProspective survey of patients with acute stroke <72 hours from onset. A structured interview was administered to the patient or primary decision-maker. If offered participation in an actual acute treatment trial, questions focused on decisions about that trial; otherwise a similar mock trial was proposed. The primary outcome was whether the subject agreed to participate in the proposed trial.
resultsA total of 200 subjects (47% patients, 53% proxies) completed the survey: mean age 63 +/- 14 years, 47% women, 44% white, 50% black. A real acute trial was offered to 22%; others were offered a mock trial. Overall, 57% (95% confidence interval: 50%-64%) of respondents stated they would participate in the proposed acute treatment trial. There were no differences with respect to age, sex, race, educational level, self-assessed stroke severity or stroke type, vascular risk factors, or comorbidities. Misconceptions about key research concepts were found in 50% but did not impact participation. Participation was associated with the perceived risk of the proposed trial intervention (p < 0.001), prior general attitudes about research (p < 0.001), and influences attributed to family, religion, and other personal beliefs (p < 0.001). Patients were more likely to participate than proxy decision-makers (p = 0.04).
conclusionsDemographic factors, clinical factors, and prior knowledge about research have little impact on the decision to participate in acute stroke clinical trials. Preexisting negative attitudes and external influences about research strongly inhibit participation. Patients are more inclined to participate than their proxy decision-makers.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.