Evidence map›Paper›PMID 19433702›Full record

Trial reportArchives of internal medicine2009

A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial.

Ulrika Gillespie, Anna Alassaad, Dan Henrohn, Hans Garmo, Margareta Hammarlund-Udenaes, Henrik Toss, Asa Kettis-Lindblad, Håkan Melhus, Claes Mörlin

5 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Archives of internal medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 293 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
293citing papers in PubMed, 24 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01337063 nacompletednot on this mapstarted 2011, after this paper: background citation

Multi-Center Medication Reconciliation Quality Improvement Study

TypeinterventionalSponsorBrigham and Women's HospitalRan2011 to 2014Enrolled1,836ConditionsAdverse Drug Events, Medication Administered in ErrorArmsMentored medication reconciliation quality improvement
NCT01906710 naunknown statusnot on this mapstarted 2013, after this paper: background citation

The Effect of Patient Centered Medication Reconciliation, Medication Review and Discharge Counseling With Information Transfer in Hospitalized Patients on Clinical and Economic Parameters: a Multicentre, Before-after Study.

TypeinterventionalSponsorClementine CM Stuijt PharmD, MScRan2013 to 2014Enrolled1,200ConditionsAdverse Drug Reaction, Medication Administered in ErrorArmsintegrated medicines management
NCT02368548 nacompletednot on this mapstarted 2012, after this paper: background citation

Randomized Clinical Trial of a Pharmaceutical Care Program in Chronic Patients Users of an Emergency Department

TypeinterventionalSponsorFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauRan2012 to 2013Enrolled100ConditionsHeart Failure, Pulmonary Disease, Chronic ObstructiveArmsPharmaceutical Care Program, Standard Care
NCT02986425 nacompletednot on this mapstarted 2016, after this paper: background citation

OPERAM: OPtimising thERapy to Prevent Avoidable Hospital Admissions in the Multimorbid Older People: a Cluster Randomised Controlled Trial

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2016 to 2019Enrolled2,009Conditions3 or More Chronic Conditions for 6 Months or Longer, 5 or More Regular DrugsArmsSTRIP intervention, Control
NCT03108092 nacompletednot on this mapstarted 2016, after this paper: background citation

Health Economic Evaluation Alongside the OPERAM Trial (OPtimising thERapy to Prevent Avoidable Hospital Admissions in the Multimorbid Older People: a Cluster Randomised Controlled Trial).

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2016 to 2019Enrolled2,009Conditions3 or More Chronic Conditions for 6 Months or Longer, 5 or More Regular DrugsArmsSTRIP intervention, Control
3 · Its place in the literature

Who cites it

293 citing papers in PubMed, 24 syntheses or guidelines pooled it.

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  6. Discharge planning from hospital.The Cochrane database of systematic reviews · 2022
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  7. Reducing medication errors for adults in hospital settings.The Cochrane database of systematic reviews · 2021
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  11. Clinical and economic impact of medication reconciliation in cancer patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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  14. Impact of medication reconciliation for improving transitions of care.The Cochrane database of systematic reviews · 2018
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  15. Hospital pharmacists working with geriatric patients in Europe: a systematic literature review.European journal of hospital pharmacy : science and practice · 2018
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233 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ulrika GillespieDivision of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. Ulrika.gillespie@farmbio.uu.se
Anna Alassaad
Dan Henrohn
Hans Garmo
Margareta Hammarlund-Udenaes
Henrik Toss
Asa Kettis-Lindblad
Håkan Melhus
Claes Mörlin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients 80 years or older are underrepresented in scientific studies. The objective of this study was to investigate the effectiveness of interventions performed by ward-based pharmacists in reducing morbidity and use of hospital care among older patients.

methodsA randomized controlled study of patients 80 years or older was conducted at the University Hospital of Uppsala, Uppsala, Sweden. Four hundred patients were recruited consecutively between October 1, 2005, and June 30, 2006, and were randomized to control (n = 201) and intervention (n = 199) groups. The interventions were performed by ward-based pharmacists. The control group received standard care without direct involvement of pharmacists at the ward level. The primary outcome measure was the frequency of hospital visits (emergency department and readmissions [total and drug-related]) during the 12-month follow-up period.

resultsThree hundred sixty-eight patients (182 in the intervention group and 186 in the control group) were analyzed. For the intervention group, there was a 16% reduction in all visits to the hospital (quotient, 1.88 vs 2.24; estimate, 0.84; 95% confidence interval [CI], 0.72-0.99) and a 47% reduction in visits to the emergency department (quotient, 0.35 vs 0.66; estimate, 0.53; 95% CI, 0.37-0.75). Drug-related readmissions were reduced by 80% (quotient, 0.06 vs 0.32; estimate, 0.20; 95% CI, 0.10-0.41). After inclusion of the intervention costs, the total cost per patient in the intervention group was $230 lower than that in the control group.

conclusionIf implemented on a population basis, the addition of pharmacists to health care teams would lead to major reductions in morbidity and health care costs.

Indexed as

Aged, 80 and overAge FactorsFemaleFollow-Up StudiesHospital CostsHospitalizationHumansMaleMorbidityPatient Care TeamPharmacy Service, HospitalSwedenTreatment Outcome

Identifiers

PMID19433702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.