ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2009
Akt2 and SGK3 are both determinants of postnatal hair follicle development.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- The regulation mechanism of different hair types in inner Mongolia cashmere goat based on PI3K-AKT pathway and FGF21.Journal of animal science · 2022Article
- Werewolf, There Wolf: Variants inGenes · 2020Article
- Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep.BMC genomics · 2020Article
- Identification of selection signals by large-scale whole-genome resequencing of cashmere goats.Scientific reports · 2017Article
- Genome-wide Target Enrichment-aided Chip Design: a 66 K SNP Chip for Cashmere Goat.Scientific reports · 2017Article
- The bald and the beautiful: hairlessness in domestic dog breeds.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Signaling involved in hair follicle morphogenesis and development.International journal of molecular sciences · 2014Review
- AKT-independent PI3-K signaling in cancer - emerging role for SGK3.Cancer management and research · 2013Review
- Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.Molecular endocrinology (Baltimore, Md.) · 2011Article
- CD34 Antigen: Determination of Specific Sites of Phosphorylation In Vitro and In Vivo.International journal of mass spectrometry · 2011Article
- Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3.Journal of gastroenterology · 2011Article
- Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3.American journal of physiology. Cell physiology · 2010Article
- Targeting SGK1 in diabetes.Expert opinion on therapeutic targets · 2009Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
SGK3, which previously has been shown to play a key role in hair follicle development in mice, is a member of the AGC family of serine-threonine kinases. Mice lacking SGK3 have abnormal follicle cycling, which begins shortly after birth and ameliorates substantially with age. However, this developmental abnormality is not recapitulated in mice lacking closely related kinases Akt1, Akt2, or Akt3. To examine whether Akt2 interacts with SGK3 in postnatal hair development, we have generated and characterized Akt2/SGK3 double knockouts (DKOs). We find that the DKO mice have a defect in hair growth that is markedly worse than that of SGK3(-/-) mice and does not ameliorate with age. Morphologically, this defect is characterized by accelerated entry into catagen and through anagen, irregular hair follicle orientation, and increased expression of sebaceous glands. The defect is preceded by a profound failure to increase follicle matrix cell nuclear beta-catenin accumulation and proliferation at the onset of morphogenesis. Furthermore, in cultured keratinocytes, transfected Akt2 and SGK3 both stimulate transcription of a beta-catenin-LEF1-dependent reporter gene. Thus, SGK3 and Akt2 both appear to play important roles in postnatal hair follicle morphogenesis, likely because of their redundant regulation of beta-catenin-dependent transcriptional processes, which control hair follicle cell proliferation.
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Registered trials
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