ArticleThe Journal of biological chemistry2009
A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Molecular characterization, expression, and apoptosis regulation of siva1 in protogynous hermaphrodite fish ricefield eel (Monopterus albus).Fish physiology and biochemistry · 2021Article
- The complex architecture of p53 binding sites.Nucleic acids research · 2021Article
- RAP80 expression in breast cancer and its relationship with apoptosis in breast cancer cells.OncoTargets and therapy · 2019Article
- Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial Cells.Molecules (Basel, Switzerland) · 2018Article
- Siva-1 emerges as a tissue-specific oncogene beyond its classic role of a proapoptotic gene.OncoTargets and therapy · 2018Review
- Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.Nucleic acids research · 2013Article
- Article
- RAP80 is critical in maintaining genomic stability and suppressing tumor development.Cancer research · 2012Article
- Multifaceted functions of Siva-1: more than an Indian God of Destruction.Protein & cell · 2012Review
- p53 Dimers associate with a head-to-tail response element to repress cyclin B transcription.PloS one · 2012Article
- The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.PLoS genetics · 2011Article
- Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets.Nucleic acids research · 2011Article
- Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies.Cancer gene therapy · 2011Review
- Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The expanding universe of p53 targets.Nature reviews. Cancer · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The ubiquitin interaction motif-containing protein RAP80 plays a key role in DNA damage response signaling. Using genomic and functional analysis, we established that the expression of the RAP80 gene is regulated in a DNA damage-responsive manner by the master regulator p53. This regulation occurs at the transcriptional level through a noncanonical p53 response element in the RAP80 promoter. Although it is inducible by p53, RAP80 is also able to regulate p53 through an association with both p53 and the E3 ubiquitin ligase HDM2, providing HDM2-dependent enhancement of p53 polyubiquitination. Depletion of RAP80 by small interfering RNA stabilizes p53, which, following DNA damage, results in an increased transactivation of several p53 target genes as well as greater apoptosis. Consistent with these observations, exogenous expression of RAP80 selectively inhibits p53-dependent transactivation of target genes in an mdm2-dependent manner in MEF cells. Thus, we identify a new DNA damage-associated role for RAP80. It can function in an autoregulatory loop consisting of RAP80, HDM2, and the p53 master regulatory network, implying an important role for this loop in genome stability and oncogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.