ArticleNucleic acids research2009
The formation pathway of i-motif tetramers.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Three- and four-stranded nucleic acid structures and their ligands.RSC chemical biology · 2025Review
- i-Motif folding intermediates with zero-nucleotide loops are trapped by 2'-fluoroarabinocytidine via F···H and O···H hydrogen bonds.Communications chemistry · 2023Article
- DNAComputational and structural biotechnology journal · 2019Article
- Assembly of supramolecular DNA complexes containing both G-quadruplexes and i-motifs by enhancing the G-repeat-bearing capacity of i-motifs.Nucleic acids research · 2017Article
- Reversible DNA i-motif to hairpin switching induced by copper(II) cations.Chemical communications (Cambridge, England) · 2015Article
- Formation and Dissociation of the Interstrand i-Motif by the Sequences d(XnC 4Y m) Monitored with Electrospray Ionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2015Article
- Shape matters: size-exclusion HPLC for the study of nucleic acid structural polymorphism.Nucleic acids research · 2014Article
- Folding and hydrodynamics of a DNA i-motif from the c-MYC promoter determined by fluorescent cytidine analogs.Biophysical journal · 2014Article
- Epigenetic modification, dehydration, and molecular crowding effects on the thermodynamics of i-motif structure formation from C-rich DNA.Biochemistry · 2014Article
- Structure and mechanical characterization of DNA i-motif nanowires by molecular dynamics simulation.Biophysical journal · 2013Article
- Junctions between i-motif tetramers in supramolecular structures.Nucleic acids research · 2012Article
- Article
- Coexistence of an ILPR i-motif and a partially folded structure with comparable mechanical stability revealed at the single-molecule level.Journal of the American Chemical Society · 2010Article
- [C7GC4]4 association into supra molecular i-motif structures.Nucleic acids research · 2010Article
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1 author.
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Abstract
The i-motif is a four-stranded structure formed by two intercalated parallel duplexes containing hemiprotonated C*C(+) pairs. In order to describe the sequence of reactions by which four C-rich strands associate, we measured the formation and dissociation rates of three [TC(n)](4) tetramers (n = 3, 4 and 5), their dissociation constant and the reaction order for tetramer formation by NMR. We find that TC(n) association results in the formation of several tetramers differing by the number of intercalated C*C(+) pairs. The formation rates of the fully and partially intercalated species are comparable but their lifetimes increase strongly with the number of intercalated C*C(+) pairs, and for this reason the single tetramer detected at equilibrium is that with optimal intercalation. The tetramer half formation times vary as the power -2 of the oligonucleotide concentration indicating that the reaction order for i-motif formation is 3. This observation is inconsistent with a model supposing association of two preformed duplex and suggests that quadruplex formation proceeds via sequential strand association into duplex and triplex intermediate species and that triplex formation is rate limiting.
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