ArticleThe Journal of cell biology2009
Regulation of glutamate receptor subunit availability by microRNAs.
Article in The Journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 58 citations in OpenAlex.
- A Review of Biomarkers of Amyotrophic Lateral Sclerosis: A Pathophysiologic Approach.International journal of molecular sciences · 2024Review
- RNA-binding FMRP and Staufen sequentially regulate the Coracle scaffold to control synaptic glutamate receptor and bouton development.Development (Cambridge, England) · 2022Article
- Local BMP signaling: A sensor for synaptic activity that balances synapse growth and function.Current topics in developmental biology · 2022Review
- Human Brain Injury and miRNAs: An Experimental Study.International journal of molecular sciences · 2019Article
- A novel mechanism of synaptic and cognitive impairments mediated via microRNA-30b in Alzheimer's disease.EBioMedicine · 2019Article
- Cereblon Maintains Synaptic and Cognitive Function by Regulating BK Channel.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Super-Resolution Single Molecule FISH at the Drosophila Neuromuscular Junction.Methods in molecular biology (Clifton, N.J.) · 2018Article
- The interplay of microRNAs and post-ischemic glutamate excitotoxicity: an emergent research field in stroke medicine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Review
- MicroRNAs: Key Regulators in the Central Nervous System and Their Implication in Neurological Diseases.International journal of molecular sciences · 2016Review
- MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity.Nature communications · 2015Article
- A Presynaptic Regulatory System Acts Transsynaptically via Mon1 to Regulate Glutamate Receptor Levels in Drosophila.Genetics · 2015Article
- Synergistic interactions between Drosophila orthologues of genes spanned by de novo human CNVs support multiple-hit models of autism.PLoS genetics · 2015Article
- Glutamatergic transmission in drug reward: implications for drug addiction.Frontiers in neuroscience · 2015Review
- Prodomain removal enables neto to stabilize glutamate receptors at the Drosophila neuromuscular junction.PLoS genetics · 2015Article
- Drosophila Syncrip modulates the expression of mRNAs encoding key synaptic proteins required for morphology at the neuromuscular junction.RNA (New York, N.Y.) · 2014Article
- Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number.Developmental biology · 2014Article
- miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling.Nature neuroscience · 2014Article
- MicroRNAs in neuronal communication.Molecular neurobiology · 2014Review
- Epigenetic memory: the Lamarckian brain.The EMBO journal · 2014Review
- MicroRNAs regulate neuronal plasticity and are involved in pain mechanisms.Frontiers in cellular neuroscience · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The efficacy of synaptic transmission depends, to a large extent, on postsynaptic receptor abundance. The molecular mechanisms controlling receptor abundance are poorly understood. We tested whether abundance of postsynaptic glutamate receptors (GluRs) in Drosophila neuromuscular junctions is controlled by microRNAs, and provide evidence that it is. We show here that postsynaptic knockdown of dicer-1, the endoribonuclease necessary for microRNA synthesis, leads to large increases in postsynaptic GluR subunit messenger RNA and protein. Specifically, we measured increases in GluRIIA and GluRIIB but not GluRIIC. Further, knockout of MiR-284, a microRNA predicted to bind to GluRIIA and GluRIIB but not GluRIIC, increases expression of GluRIIA and GluRIIB but not GluRIIC proportional to the number of predicted binding sites in each transcript. Most of the de-repressed GluR protein, however, does not appear to be incorporated into functional receptors, and only minor changes in synaptic strength are observed, which suggests that microRNAs primarily regulate Drosophila receptor subunit composition rather than overall receptor abundance or synaptic strength.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.