ArticleThe Journal of cell biology2009
The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster.
Article in The Journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 88 citations in OpenAlex.
- Host-transposable element coexistence: a matter of resistance, tolerance and trade-off.The EMBO journal · 2026Review
- Reproductive phasiRNAs are the piRNAs of plants.Trends in genetics : TIG · 2026Review
- Asymmetric Chromosome Establishment and Segregation During Germline Stem Cell Division.Advances in experimental medicine and biology · 2026Review
- Comparative functional and evolutionary analysis of essential germline stem cell genes across the genus Drosophila and two outgroup species.G3 (Bethesda, Md.) · 2025Article
- Molecular insights into the Drosophila piRNA pathway via systematic ReLo protein interaction screening and structure prediction.Nucleic acids research · 2025Article
- A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals.Nature reviews. Molecular cell biology · 2025Review
- piRNA Defense Against Endogenous Retroviruses.Viruses · 2024Review
- Review
- Article
- Armitage determines Piwi-piRISC processing from precursor formation and quality control to inter-organelle translocation.EMBO reports · 2020Article
- Assembly and Function of Gonad-Specific Non-Membranous Organelles inNon-coding RNA · 2019Review
- Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery.Genes & development · 2019Article
- Requirements for multivalent Yb body assembly in transposon silencing in Drosophila.EMBO reports · 2019Article
- Yb body assembly on theMolecular biology of the cell · 2019Article
- PIWI-interacting RNAs: small RNAs with big functions.Nature reviews. Genetics · 2019Review
- Article
- Review
- piRNA-Guided Genome Defense: From Biogenesis to Silencing.Annual review of genetics · 2018Review
- Transcriptomic and functional analyses of the piRNA pathway in the Chagas disease vector Rhodnius prolixus.PLoS neglected tropical diseases · 2018Article
- Protecting and Diversifying the Germline.Genetics · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Yb regulates the proliferation of both germline and somatic stem cells in the Drosophila melanogaster ovary by activating piwi and hh expression in niche cells. In this study, we show that Yb protein is localized as discrete cytoplasmic spots exclusively in the somatic cells of the ovary and testis. These spots, which are different from all known cytoplasmic structures in D. melanogaster, are evenly electron-dense spheres 1.5 microm in diameter (herein termed the Yb body). The Yb body is frequently associated with mitochondria and a less electron-dense sphere of similar size that appears to be RNA rich. There are one to two Yb bodies/cell, often located close to germline cells. The N-terminal region of Yb is required for hh expression in niche cells, whereas the C-terminal region is required for localization to Yb bodies. The entire Yb protein is necessary for piwi expression in niche cells. A double mutant of Yb and a novel locus show male germline loss, revealing a function for Yb in male germline stem cell maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.