ArticleMolecular and cellular biology2009
Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 56 citations in OpenAlex.
- Clinical immunology in chromatinopathies: a scoping review.Frontiers in immunology · 2026Article
- CBP/P300 Inhibition Impairs CD4+ T Cell Activation: Implications for Autoimmune Disorders.Biomedicines · 2024Article
- Signals for antigen-independent differentiation of memory CD8Cellular and molecular life sciences : CMLS · 2021Review
- The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors.Cells · 2021Review
- Allotransplantation Is Associated With Exacerbation of CD8 T-Cell Senescence: The Particular Place of the Innate CD8 T-Cell Component.Frontiers in immunology · 2021Article
- Histone acetyltransferase CBP is critical for conventional effector and memory T-cell differentiation in mice.The Journal of biological chemistry · 2019Article
- Invariant NKT Cells and Control of the Thymus Medulla.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- Foreign antigen-independent memory-phenotype CD4Nature reviews. Immunology · 2018Article
- Lineage Differentiation Program of Invariant Natural Killer T Cells.Immune network · 2017Review
- Antigen-inexperienced memory CD8Nature reviews. Immunology · 2017Article
- The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma.Cancer discovery · 2017Article
- IL-4 and IL-15 promotion of virtual memory CD8European journal of immunology · 2016Article
- NFAT2 Regulates Generation of Innate-Like CD8Frontiers in immunology · 2016Article
- IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection.PLoS pathogens · 2015Article
- Thymic low affinity/avidity interaction selects natural Th1 cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Innate memory T cells.Advances in immunology · 2015Review
- Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function.Molecular and cellular biology · 2014Article
- Jarid2 is induced by TCR signalling and controls iNKT cell maturation.Nature communications · 2014Article
- Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Dendritic cell-MHC class II and Itk regulate functional development of regulatory innate memory CD4+ T cells in bone marrow transplantation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Defining the chromatin modifications and transcriptional mechanisms that direct the development of different T-cell lineages is a major challenge in immunology. The transcriptional coactivators CREB binding protein (CBP) and the closely related p300, which comprise the KAT3 family of histone/protein lysine acetyltransferases, interact with over 50 T-lymphocyte-essential transcriptional regulators. We show here that CBP, but not p300, modulates the thymic development of conventional adaptive T cells versus those having unconventional innate functions. Conditional inactivation of CBP in the thymus yielded CD8 single-positive (SP) thymocytes with an effector-, memory-, or innate-like T-cell phenotype. In this regard, CD8 SP thymocytes in CBP mutant mice were phenotypically similar to those reported for Itk and Rlk protein tyrosine kinase mutants, including the increased expression of the T-cell master regulatory transcription factor eomesodermin (Eomes) and the interleukin-2 and -15 receptor beta chain (CD122) and an enhanced ability to rapidly produce gamma interferon. CBP was required for the expression of the Itk-dependent genes Egr2, Egr3, and Il2, suggesting that CBP helps mediate Itk-responsive transcription. CBP therefore defines a nuclear component of the signaling pathways that demarcate the development of innate and adaptive naïve CD8(+) T cells in the thymus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.