Evidence map›Paper›PMID 19433247›Full record

ReviewMolecular and cellular endocrinology2009

Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome.

Nira Ben-Jonathan, Eric R Hugo, Terry D Brandebourg

Open access · greenAbstract readReview
In one paragraph

Review in Molecular and cellular endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 1 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 1 synthesis or guideline pooled it, 263 citations in OpenAlex.

  1. The association between bisphenol A exposure and type-2 diabetes: a world systematic review.Environmental science and pollution research international · 2016
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Food science & nutrition · 2023
    Article
  9. Article
  10. Review
  11. Are BPA Substitutes as Obesogenic as BPA?International journal of molecular sciences · 2022
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nira Ben-JonathanDepartment of Cancer and Cell Biology, University of Cincinnati, OH 45267, USA. Nira.Ben-Jonathan@uc.edu
Eric R Hugo
Terry D Brandebourg
University of Cincinnati · USUniversity of Cincinnati Medical Center · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4M
Prolactin as a Growth Factor in Breast CancerR01CA096613 · NCI · UNIVERSITY OF CINCINNATI · PI BEN-JONATHAN, NIRA · 2004 to 2013
$2.7M
GENETIC ANALYSIS OF MULTIDRUG RESISTANCE GENESZ01BC005725 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DEAN, MICHAEL · 1996 to 2008
$1.9M
Xenoestrogens: Genomic and Non-genomic MechanismsR01ES012212 · NIEHS · UNIVERSITY OF CINCINNATI · PI BEN-JONATHAN, NIRA · 2003 to 2006
$1.1M
Exposure to Bisphenol A: Inhibition of Adiponectin Release by Human AdipocytesR21ES016803 · NIEHS · UNIVERSITY OF CINCINNATI · PI BEN-JONATHAN, NIRA · 2008 to 2009
$543k
Intramural NIH HHS Z01 BC005725NCI NIH HHS CA096613NCI NIH HHS R01 CA096613NIEHS NIH HHS ES012212NIEHS NIH HHS ES016803NIEHS NIH HHS P30 ES006096NIEHS NIH HHS P30 ES06096NIEHS NIH HHS R01 ES012212NIEHS NIH HHS R21 ES016803
6 · The paper itself

Abstract

Bisphenol A (BPA) is one of the most prevalent and best studied endocrine disruptors. After years of exposure to consumer products containing BPA, most individuals tested have circulating BPA at the low nanomolar levels. In addition to its well documented actions on the reproductive system, BPA exerts a wide variety of metabolic effects. This review summarizes recent findings on the ability of BPA, at environmentally relevant doses, to inhibit adiponectin and stimulate the release of inflammatory adipokines such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) from human adipose tissue. Expression of several classical and non-classical estrogen receptors in human adipose tissue raises the possibility of their involvement as mediators of BPA actions. The implications of these observations to the obesity-related metabolic syndrome and its sequelae are discussed.

Indexed as

Adipose TissueAdipokinesAdiponectinAir Pollutants, OccupationalAnimalsBenzhydryl CompoundsBisphenol A CompoundsEndocrine DisruptorsEstrogens, Non-SteroidalHumansInterleukin-6Metabolic SyndromeMolecular StructureObesityPhenolsReceptors, EstrogenAdipokinesAdiponectinAir Pollutants, OccupationalBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEndocrine DisruptorsEstrogens, Non-SteroidalInterleukin-6PhenolsReceptors, EstrogenTumor Necrosis Factor-alpha

Identifiers

PMID19433247
PMCPMC2775425
OpenAlexW2153112599

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.