ArticleMolecular pain2009
Inhibitory coupling between inhibitory interneurons in the spinal cord dorsal horn.
Article in Molecular pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Neuroligins and Neuropathic Pain: Insights into Synaptic Plasticity and Pain Transmission.Biology · 2026Review
- Electrophysiological Properties of Substantia Gelatinosa Neurons in the Preparation of a Slice of Middle-Aged Rat Spinal Cord.Frontiers in aging neuroscience · 2021Article
- Reviewing the case for compromised spinal inhibition in neuropathic pain.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- KIF2A characterization after spinal cord injury.Cellular and molecular life sciences : CMLS · 2019Article
- Itch suppression in mice and dogs by modulation of spinal α2 and α3GABANature communications · 2018Article
- Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Peripheral afferents and spinal inhibitory system in dynamic and static mechanical allodynia.Pain · 2017Review
- Interleukin-1 receptor type 1 is overexpressed in neurons but not in glial cells within the rat superficial spinal dorsal horn in complete Freund adjuvant-induced inflammatory pain.Journal of neuroinflammation · 2017Article
- Article
- Synaptic ultrastructure changes in trigeminocervical complex posttrigeminal nerve injury.The Journal of comparative neurology · 2016Article
- Age-dependent sensitization of cutaneous nociceptors during developmental inflammation.Molecular pain · 2014Article
- Long-term potentiation of glycinergic synapses triggered by interleukin 1β.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn.The Journal of physiology · 2014Article
- Normal and abnormal coding of somatosensory stimuli causing pain.Nature neuroscience · 2014Review
- Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release.Annual review of physiology · 2014Review
- The heterogeneity in GABAA receptor-mediated IPSC kinetics reflects heterogeneity of subunit composition among inhibitory and excitatory interneurons in spinal lamina II.Frontiers in cellular neuroscience · 2014Article
- Chloride extrusion enhancers as novel therapeutics for neurological diseases.Nature medicine · 2013Article
- Dynamic effects of TNF-α on synaptic transmission in mice over time following sciatic nerve chronic constriction injury.Journal of neurophysiology · 2013Article
- Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold.Neuron · 2013Article
- Differential balance of prefrontal synaptic activity in successful versus unsuccessful cognitive aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local inhibitory interneurons in the dorsal horn play an important role in the control of excitability at the segmental level and thus determine how nociceptive information is relayed to higher structures. Regulation of inhibitory interneuron activity may therefore have critical consequences on pain perception. Indeed, disinhibition of dorsal horn neuronal networks disrupts the balance between excitation and inhibition and is believed to be a key mechanism underlying different forms of pain hypersensitivity and chronic pain states. In this context, studying the source and the synaptic properties of the inhibitory inputs that the inhibitory interneurons receive is important in order to predict the impact of drug action at the network level. To address this, we studied inhibitory synaptic transmission in lamina II inhibitory interneurons identified under visual guidance in spinal slices taken from transgenic mice expressing enhanced green fluorescent protein (EGFP) under the control of the GAD promoter. The majority of these cells fired tonically to a long depolarizing current pulse. Monosynaptically evoked inhibitory postsynaptic currents (eIPSCs) in these cells were mediated by both GABAA and glycine receptors. Consistent with this, both GABAA and glycine receptor-mediated miniature IPSCs were recorded in all of the cells. These inhibitory inputs originated at least in part from local lamina II interneurons as verified by simultaneous recordings from pairs of EGFP+ cells. These synapses appeared to have low release probability and displayed potentiation and asynchronous release upon repeated activation. In summary, we report on a previously unexamined component of the dorsal horn circuitry that likely constitutes an essential element of the fine tuning of nociception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.