ArticleBMC genomics2009
Comparative genomics of Toll-like receptor signalling in five species.
Article in BMC genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
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- Genomic Association between SNP Markers and Diseases in the "Curraleiro Pé-Duro" Cattle.Genes · 2021Article
- Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier.International journal of molecular sciences · 2021Review
- Population structure and genomic inbreeding in nine Swiss dairy cattle populations.Genetics, selection, evolution : GSE · 2017Article
- Differential macrophage function in Brown Swiss and Holstein Friesian cattle.Veterinary immunology and immunopathology · 2016Article
- Evidence for adaptation of porcine Toll-like receptors.Immunogenetics · 2016Article
- Genetic Variation of Goat Interferon Regulatory Factor 3 Gene and Its Implication in Goat Evolution.PloS one · 2016Article
- Article
- Recent artificial selection in U.S. Jersey cattle impacts autozygosity levels of specific genomic regions.BMC genomics · 2015Article
- A joint analysis to identify loci underlying variation in nematode resistance in three European sheep populations.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2014Article
- A comparative review of toll-like receptor 4 expression and functionality in different animal species.Frontiers in immunology · 2014Review
- Article
- Genes controlling vaccine responses and disease resistance to respiratory viral pathogens in cattle.Veterinary immunology and immunopathology · 2012Article
- Association of TLR4 polymorphisms with subclinical mastitis in Brazilian holsteins.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2012Article
- Identification of single nucleotide polymorphisms in the bovine Toll-like receptor 1 gene and association with health traits in cattle.Veterinary research · 2012Article
- The molecular pathways underlying host resistance and tolerance to pathogens.Frontiers in genetics · 2012Article
- Evolution of the bovine TLR gene family and member associations with Mycobacterium avium subspecies paratuberculosis infection.PloS one · 2011Article
- Quantitative trait loci for variation in immune response to a Foot-and-Mouth Disease virus peptide.BMC genetics · 2010Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundOver the last decade, several studies have identified quantitative trait loci (QTL) affecting variation of immune related traits in mammals. Recent studies in humans and mice suggest that part of this variation may be caused by polymorphisms in genes involved in Toll-like receptor (TLR) signalling. In this project, we used a comparative approach to investigate the importance of TLR-related genes in comparison with other immunologically relevant genes for resistance traits in five species by associating their genomic location with previously published immune-related QTL regions.
resultsWe report the genomic localisation of TLR1-10 and ten associated signalling molecules in sheep and pig using in-silico and/or radiation hybrid (RH) mapping techniques and compare their positions with their annotated homologues in the human, cattle and mouse whole genome sequences. We also report medium-density RH maps for porcine chromosomes 8 and 13. A comparative analysis of the positions of previously published relevant QTLs allowed the identification of homologous regions that are associated with similar health traits in several species and which contain TLR related and other immunologically relevant genes. Additional evidence was gathered by examining relevant gene expression and association studies.
conclusionThis comparative genomic approach identified eight genes as potentially causative genes for variations of health related traits. These include susceptibility to clinical mastitis in dairy cattle, general disease resistance in sheep, cattle, humans and mice, and tolerance to protozoan infection in cattle and mice. Four TLR-related genes (TLR1, 6, MyD88, IRF3) appear to be the most likely candidate genes underlying QTL regions which control the resistance to the same or similar pathogens in several species. Further studies are required to investigate the potential role of polymorphisms within these genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.