ArticleBiophysical journal1988
Glutamate receptor channel kinetics: the effect of glutamate concentration.
Article in Biophysical journal, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Markov models and long-term memory in ion channels: A contradiction in terms?Biophysical journal · 2025Article
- Capsaicin activation of the pain receptor, VR1: multiple open states from both partial and full binding.Biophysical journal · 2003Article
- Potassium channels of adult locust (Schistocerca gregaria) muscle.Pflugers Archiv : European journal of physiology · 1996Article
- Description of interacting channel gating using a stochastic Markovian model.Bulletin of mathematical biology · 1996Article
- Testing for microscopic reversibility in the gating of maxi K+ channels using two-dimensional dwell-time distributions.Biophysical journal · 1994Article
- Multiphasic desensitization of the GABAA receptor in outside-out patches.Biophysical journal · 1994Article
- Gating kinetics of the quisqualate-sensitive glutamate receptor of locust muscle studied using agonist concentration jumps and computer simulations.Biophysical journal · 1993Article
- Single ion channel models incorporating aggregation and time interval omission.Biophysical journal · 1993Article
- Accounting for the Ca(2+)-dependent kinetics of single large-conductance Ca(2+)-activated K+ channels in rat skeletal muscle.The Journal of physiology · 1991Article
- Diffusion model in ion channel gating. Extension to agonist-activated ion channels.Biophysical journal · 1991Article
- Solubilization and purification of a putative quisqualate-sensitive glutamate receptor from crustacean muscle.The Biochemical journal · 1991Article
- Estimating kinetic parameters for single channels with simulation. A general method that resolves the missed event problem and accounts for noise.Biophysical journal · 1990Article
- Glutamate receptor-channel gating. Maximum likelihood analysis of gigaohm seal recordings from locust muscle.Biophysical journal · 1990Article
- Divalent cation activation and inhibition of single calcium release channels from sheep cardiac sarcoplasmic reticulum.The Journal of general physiology · 1990Article
- Intraburst kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture.The Journal of physiology · 1990Article
- Rapid activation, desensitization, and resensitization of synaptic channels of crayfish muscle after glutamate pulses.Biophysical journal · 1990Article
- Markov, fractal, diffusion, and related models of ion channel gating. A comparison with experimental data from two ion channels.Biophysical journal · 1989Article
- Argiopine blocks glutamate-activated single-channel currents on crayfish muscle by two mechanisms.The Journal of physiology · 1989Article
- Kinetic time constants independent of previous single-channel activity suggest Markov gating for a large conductance Ca-activated K channel.The Journal of general physiology · 1989Article
- Adjacent interval analysis distinguishes among gating mechanisms for the fast chloride channel from rat skeletal muscle.The Journal of physiology · 1989Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single channel recordings from the locust muscle D-glutamate receptor channel were obtained using glutamate concentrations ranging from 10(-6) to 10(-2) M. Channel kinetics were analyzed to aid in the development of a model for the gating mechanism. Analysis of channel dwell time histograms demonstrated that the channel possessed multiple open and closed states at concentrations of glutamate between 10(-5) and 10(-2) M. Correlations between successive dwell times showed that the gating mechanism was nonlinear (i.e., branched or cyclic) over the same glutamate concentration range. The glutamate concentration dependence of the channel open probability, and of the event frequency, was used to explore two possible allosteric gating mechanisms in more detail.
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