ArticleAngewandte Chemie (International ed. in English)2009
Fluorescence detection of single-nucleotide polymorphisms with a single, self-complementary, triple-stem DNA probe.
Article in Angewandte Chemie (International ed. in English), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Design of mismatch closure for enhanced specificity in DNA strand displacement reactions.Nucleic acids research · 2025Article
- Nonequilibrium hybridization-driven CRISPR/Cas adapter with extended energetic penalty for discrimination of single-nucleotide variants.Nucleic acids research · 2025Article
- Article
- Recent advances in enzyme-free and enzyme-mediated single-nucleotide variation assayNational science review · 2024Review
- Utilization of chromogenic enzyme substrates for signal amplification in multiplexed detection of biomolecules using surface mass spectrometry.Sensors and actuators. B, Chemical · 2021Article
- Expanding detection windows for discriminating single nucleotide variants using rationally designed DNA equalizer probes.Nature communications · 2020Article
- Enhanced Hybridization Selectivity Using Structured GammaPNA Probes.Molecules (Basel, Switzerland) · 2020Article
- Simulation-guided engineering of an enzyme-powered three dimensional DNA nanomachine for discriminating single nucleotide variants.Chemical science · 2018Article
- Endonuclease IV recognizes single base mismatch on the eighth base 3' to the abasic site in DNA strands for ultra-selective and sensitive mutant-type DNA detection.RSC advances · 2018Article
- DNA terminal structure-mediated enzymatic reaction for ultra-sensitive discrimination of single nucleotide variations in circulating cell-free DNA.Nucleic acids research · 2018Article
- A branch-migration based fluorescent probe for straightforward, sensitive and specific discrimination of DNA mutations.Nucleic acids research · 2017Article
- Ultra-specific discrimination of single-nucleotide mutations using sequestration-assisted molecular beacons.Chemical science · 2017Article
- Nonequilibrium Hybridization Enables Discrimination of a Point Mutation within 5-40 °C.Journal of the American Chemical Society · 2016Article
- Highly specific SNP detection using 2D graphene electronics and DNA strand displacement.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A universal probe design for colorimetric detection of single-nucleotide variation with visible readout and high specificity.Scientific reports · 2016Article
- Spectra, Stability and Labeling of a Novel Carbazole Derivative as a Fluorescent Turn-on DNA Probe.Journal of fluorescence · 2015Article
- Simulation-guided DNA probe design for consistently ultraspecific hybridization.Nature chemistry · 2015Article
- Protected DNA strand displacement for enhanced single nucleotide discrimination in double-stranded DNA.Scientific reports · 2015Article
- Enzyme-mediated single-nucleotide variation detection at room temperature with high discrimination factor.Chemical science · 2015Article
- Amplified single base-pair mismatch detection via aggregation of exonuclease-sheared gold nanoparticles.Analytical chemistry · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Singled out for its singularity: In a single-step, single-component, fluorescence-based method for the detection of single-nucleotide polymorphisms at room temperature, the sensor is comprised of a single, self-complementary DNA strand that forms a triple-stem structure. The large conformational change that occurs upon binding to perfectly matched (PM) targets results in a significant increase in fluorescence (see picture; F = fluorophore, Q = quencher).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.