ReviewClinical reviews in allergy & immunology2010
The role of Toll-like receptor signaling in human immunodeficiencies.
Review in Clinical reviews in allergy & immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Immunotherapeutic Implications of Toll-like Receptors Activation in Tumor Microenvironment.Pharmaceutics · 2022Review
- Alternative pre-mRNA splicing as a mechanism for terminating Toll-like Receptor signaling.Frontiers in immunology · 2022Review
- IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature.Frontiers in pediatrics · 2017Article
- Fatal pneumococcal meningitis in a 7-year-old girl with interleukin-1 receptor activated kinase deficiency (IRAK-4) despite prophylactic antibiotic and IgG responses to Streptococcus pneumoniae vaccines.Journal of clinical immunology · 2014Article
- Prior TLR5 induction in human T cells results in a transient potentiation of subsequent TCR-induced cytokine production.Molecular immunology · 2014Article
- Bacterial interference with canonical NFκB signalling.Microbiology (Reading, England) · 2013Review
- Modulation of IL-8 boosted by Mycoplasma pneumoniae lysate in human airway epithelial cells.Journal of clinical immunology · 2013Article
- TRAF molecules in cell signaling and in human diseases.Journal of molecular signaling · 2013Article
- Notch and PKC are involved in formation of the lateral region of the dorso-ventral axis in Drosophila embryos.PloS one · 2013Article
- Complete dependence on IRAK4 kinase activity in TLR2, but not TLR4, signaling pathways underlies decreased cytokine production and increased susceptibility to Streptococcus pneumoniae infection in IRAK4 kinase-inactive mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The future of autoimmunity.Clinical reviews in allergy & immunology · 2012Article
- Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits.PloS one · 2012Article
- cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms.Molecular cell · 2011Article
- Article
- Controlling the response: predictive modeling of a highly central, pathogen-targeted core response module in macrophage activation.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Through the last decade, clinical immunology has witnessed a considerable progress in understanding the role of the innate immunity in human host defense, with Toll-like receptors (TLRs) being the most extensively innate immune receptors investigated. Growing literature documents the relevance of TLR signaling pathways to human disease, revealing a small, but expanding, group of new monogenic primary immunodeficiencies, in patients with various infectious diseases, previously considered as of unexplained "idiopathic" origin. Herein, we review these recently described deficiencies. Autosomal recessive IRAK-4 and myeloid differentiation factor 88 deficiencies were reported in 2003 and 2008, respectively, conferring predisposition to pyogenic bacterial infections, and autosomal recessive UNC93B1 and autosomal dominant TLR3 deficiencies were reported in 2006 and 2007, respectively, conferring predisposition to herpes simplex encephalitis. Furthermore, we highlight the published data associating TLR polymorphism with an altered susceptibility to infectious diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.