ReviewJournal of neuro-oncology2009
Origins and clinical implications of the brain tumor stem cell hypothesis.
Review in Journal of neuro-oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- miRNA-regulated cancer stem cells: understanding the property and the role of miRNA in carcinogenesis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Molecular heterogeneity of glioblastomas: does location matter?Oncotarget · 2016Article
- Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases.Journal of central nervous system disease · 2016Review
- Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo.Oncotarget · 2014Article
- Prospective therapies for high-grade glial tumours: A literature review.Annals of medicine and surgery (2012) · 2014Review
- ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma.Experimental hematology & oncology · 2013Article
- Therapy targets in glioblastoma and cancer stem cells: lessons from haematopoietic neoplasms.Journal of cellular and molecular medicine · 2013Review
- Similarity on neural stem cells and brain tumor stem cells in transgenic brain tumor mouse models.Neural regeneration research · 2013Article
- Cortical dysplasia: a possible substrate for brain tumors.Future oncology (London, England) · 2012Article
- MicroRNAs as regulators of neural stem cell-related pathways in glioblastoma multiforme.Molecular neurobiology · 2011Review
- Non-viral gene delivery nanoparticles based on poly(β-amino esters) for treatment of glioblastoma.Biomaterials · 2011Article
- The Oncogenic Potential of Mesenchymal Stem Cells in the Treatment of Cancer: Directions for Future Research.Current immunology reviews · 2010Article
- Primary brain tumors, neural stem cell, and brain tumor cancer cells: where is the link?Neuropharmacology · 2010Review
- Mouse models for cancer stem cell research.Toxicologic pathology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
With the advent of the cancer stem cell hypothesis, the field of cancer research has experienced a revolution in how we think of and approach cancer. The discovery of "brain tumor stem cells" has offered an explanation for several long-standing conundrums on why brain tumors behave the way they do to treatment. Despite the great amount of research that has been done in order to understand the molecular aspects of malignant gliomas, the prognosis of brain tumors remains dismal. The slow progress in extending the survival of patients with malignant CNS neoplasms is very likely due to poor understanding of the cell of origin in these tumors. This review article discusses the progress in our understanding of brain tumor stem cells as the cell of origin in brain cancers. We review the different proposed mechanisms of how brain tumor stem cells may originate, the intracellular pathways disrupted in the pathogenesis of BTSCs, the molecular markers used to identify BTSCs, the molecular mechanisms of cancer initiation and progression, and finally the clinical implications of this research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.