ArticleJournal of gastroenterology2009
Unbalanced expression of protease-activated receptors-1 and -2 in the colon of diarrhea-predominant irritable bowel syndrome patients.
Article in Journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review.Journal of gastroenterology · 2011Pooled it
- Inhibition of Serine Proteases as a Novel Therapeutic Strategy for Abdominal Pain in IBS.Frontiers in physiology · 2022Review
- Proteolytic Cleavage of Bioactive Peptides and Protease-Activated Receptors in Acute and Post-Colitis.International journal of molecular sciences · 2021Article
- The functional role of protease-activated receptors on contractile responses by activation of CaAmerican journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases.World journal of gastroenterology · 2016Review
- Analysis of Gastric and Duodenal Eosinophils in Children with Abdominal Pain Related Functional Gastrointestinal Disorders According to Rome III Criteria.Journal of neurogastroenterology and motility · 2016Article
- Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome.Gut and liver · 2016Article
- Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside.Journal of neurogastroenterology and motility · 2016Review
- Gut pain & visceral hypersensitivity.British journal of pain · 2013Article
- Probiotics VSL#3 protect against development of visceral pain in murine model of irritable bowel syndrome.PloS one · 2013Article
- Mast cells: an expanding pathophysiological role from allergy to other disorders.Naunyn-Schmiedeberg's archives of pharmacology · 2012Review
- Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation.Journal of neuroinflammation · 2012Article
- Lesioning of TRPV1 expressing primary afferent neurons prevents PAR-2 induced motility, but not mechanical hypersensitivity in the rat colon.Neurogastroenterology and motility · 2012Article
- The expression of protease-activated receptor 2 and 4 in the colon of irritable bowel syndrome patients.Digestive diseases and sciences · 2012Article
- Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome.World journal of gastroenterology · 2010Article
- Current insights into the innate immune system dysfunction in irritable bowel syndrome.Annals of gastroenterologyReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study is to determine whether a changed expression ratio of PAR-1 and PAR-2 in the colon is associated with diarrhea-predominant IBS patients.
methodsPAR-1, -2, thrombin, mast cell tryptase, tryptophan hydroxylase (TPH), and chromgranin A (ChrA) in colonic biopsy samples from 10 diarrhea-predominant IBS patients and 13 healthy control subjects were semiquantified with immunofluorescence and image analysis. Serotonin concentrations in biopsy samples were evaluated by capillary electrophoresis.
resultsSignificantly lower expression of PAR-1 and higher expression of mast cell tryptase was detected in the colons of patients, with statistically unchanged expression of PAR-2. Thrombin-, TPH-, and ChrA-positive cells were markedly increased in IBS patients, but no significant difference in serotonin concentration existed in the colons between two groups. The ratio of PAR-1/PAR-2 expression was significantly decreased in patients (0.33+/-0.19 versus 0.66+/-0.22, P=0.001) and negatively correlated to ChrA-positive cells.
conclusionsChanged expression ratio of PAR-1 to PAR-2 in the colon is connected with diarrhea-predominant IBS patients. Methods to restore an appropriate balance of PAR-1 and PAR-2 activation in the colon may offer a promising future therapeutic strategy for IBS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.