ArticleNature chemical biology2009
Brownian search-and-catch mechanism for myosin-VI steps.
Article in Nature chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Active fluctuations of cytoplasmic actomyosin networks facilitate dynein-driven transport.iScience · 2025Article
- Single-Molecule Investigation of Load-Dependent Actomyosin Dissociation Kinetics for Cardiac and Slow Skeletal Myosin.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Autoregulation and dual stepping mode of MYA2, an Arabidopsis myosin XI responsible for cytoplasmic streaming.Scientific reports · 2022Article
- Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance.International immunology · 2019Article
- Coarse-Grained Protein Dynamics Studies Using Elastic Network Models.International journal of molecular sciences · 2018Review
- Structure of actomyosin rigour complex at 5.2 Å resolution and insights into the ATPase cycle mechanism.Nature communications · 2017Article
- Single molecule detection, thermal fluctuation and life.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Review
- A programmable DNA origami nanospring that reveals force-induced adjacent binding of myosin VI heads.Nature communications · 2016Article
- Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin-microtubule interface.Nature communications · 2016Article
- Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules.Nature communications · 2015Article
- Nonequilibrium dissipation-free transport in F₁-ATPase and the thermodynamic role of asymmetric allosterism.Biophysical journal · 2014Article
- Myosin V is a biological Brownian machine.Biophysics (Nagoya-shi, Japan) · 2014Review
- Interrogating biology with force: single molecule high-resolution measurements with optical tweezers.Biophysical journal · 2013Review
- DNA target sequence identification mechanism for dimer-active protein complexes.Nucleic acids research · 2013Article
- Measuring collective transport by defined numbers of processive and nonprocessive kinesin motors.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Muscle contraction mechanism based on single molecule measurements.Journal of muscle research and cell motility · 2012Article
- Membrane-induced lever arm expansion allows myosin VI to walk with large and variable step sizes.The Journal of biological chemistry · 2012Article
- Ultrafast force-clamp spectroscopy of single molecules reveals load dependence of myosin working stroke.Nature methods · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cargo transporter myosin-VI processively walks along actin filaments using its two heads. Here we use single-molecule nanometry to show that the strong binding by myosin heads to actin is greatly accelerated (approximately 30-fold) when backward strain is applied to weakly bound heads during the actin search. We propose that the myosin head searches for the forward actin target by Brownian motion and catches the actin in a strain-dependent manner.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.