ArticleDevelopment (Cambridge, England)2009
Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Diverse and dynamic forms of gene regulation by the S. cerevisiae histone methyltransferase Set1.Current genetics · 2023Review
- Genome-wide CRISPR-Cas9 screen reveals a persistent null-hyphal phenotype that maintains high carotenoid production in Yarrowia lipolytica.Biotechnology and bioengineering · 2022Article
- PTIP Inhibits Cell Invasion in Esophageal Squamous Cell CarcinomaFrontiers in oncology · 2021Article
- KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.Theranostics · 2021Article
- Regeneration after acute kidney injury requires PTIP-mediated epigenetic modifications.JCI insight · 2020Article
- The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic.eLife · 2016Article
- Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Mechanisms of gene activation and repression by Pax proteins in the developing kidney.Pediatric nephrology (Berlin, Germany) · 2014Review
- Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes.Developmental biology · 2013Article
- Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage.PloS one · 2013Article
- A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability.Human molecular genetics · 2012Article
- The COMPASS family of H3K4 methylases in Drosophila.Molecular and cellular biology · 2011Article
- Patterning and early cell lineage decisions in the developing kidney: the role of Pax genes.Pediatric nephrology (Berlin, Germany) · 2011Review
- Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes.The Journal of clinical investigation · 2011Article
- Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus.Molecular and cellular biology · 2011Article
- Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.PLoS genetics · 2010Article
- PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.Science (New York, N.Y.) · 2010Article
- Advances in early kidney specification, development and patterning.Development (Cambridge, England) · 2009Review
- The specification and maintenance of renal cell types by epigenetic factors.Organogenesis · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Development of the fruit fly Drosophila depends in part on epigenetic regulation carried out by the concerted actions of the Polycomb and Trithorax group of proteins, many of which are associated with histone methyltransferase activity. Mouse PTIP is part of a histone H3K4 methyltransferase complex and contains six BRCT domains and a glutamine-rich region. In this article, we describe an essential role for the Drosophila ortholog of the mammalian Ptip (Paxip1) gene in early development and imaginal disc patterning. Both maternal and zygotic ptip are required for segmentation and axis patterning during larval development. Loss of ptip results in a decrease in global levels of H3K4 methylation and an increase in the levels of H3K27 methylation. In cell culture, Drosophila ptip is required to activate homeotic gene expression in response to the derepression of Polycomb group genes. Activation of developmental genes is coincident with PTIP protein binding to promoter sequences and increased H3K4 trimethylation. These data suggest a highly conserved function for ptip in epigenetic control of development and differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.