ArticleExperimental physiology2009
Effect of protease-activated receptor 2 activation on single TRPV1 channel activities in rat vagal pulmonary sensory neurons.
Article in Experimental physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Neuroimmune interactions: The bridge between inflammatory bowel disease and the gut microbiota.Clinical and translational medicine · 2025Review
- Mast cell-sensory neuron crosstalk in allergic diseases.The Journal of allergy and clinical immunology · 2024Review
- Bibliometric analysis of recent research on the association between TRPV1 and inflammation.Channels (Austin, Tex.) · 2023Article
- A mast cell-thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis.Science immunology · 2023Article
- Neuroanatomical and neurophysiological evidence of pulmonary nociceptor and carotid chemoreceptor convergence in the nucleus tractus solitarius and nucleus ambiguus.Journal of neurophysiology · 2022Article
- Nociceptor Signalling through ion Channel Regulation via GPCRs.International journal of molecular sciences · 2019Review
- Mechanisms of Probiotic VSL#3 in a Rat Model of Visceral Hypersensitivity Involves the Mast Cell-PAR2-TRPV1 Pathway.Digestive diseases and sciences · 2019Article
- Vagal Afferent Innervation of the Airways in Health and Disease.Physiological reviews · 2016Review
- Oxidative stress as activators of sensory nerves for cough.Pulmonary pharmacology & therapeutics · 2015Review
- Sensory nerve terminal mitochondrial dysfunction induces hyperexcitability in airway nociceptors via protein kinase C.Molecular pharmacology · 2014Article
- Urinary plasmin inhibits TRPV5 in nephrotic-range proteinuria.Journal of the American Society of Nephrology : JASN · 2012Article
- House dust mite potentiates capsaicin-evoked Ca2+ transients in mouse pulmonary sensory neurons via activation of protease-activated receptor-2.Experimental physiology · 2012Article
- Essential role of mast cells in the visceral hyperalgesia induced by T. spiralis infection and stress in rats.Mediators of inflammation · 2012Article
- TRP channels in neurogastroenterology: opportunities for therapeutic intervention.British journal of pharmacology · 2011Review
- Thrombin and trypsin directly activate vagal C-fibres in mouse lung via protease-activated receptor-1.The Journal of physiology · 2010Article
- Regulation of acid signaling in rat pulmonary sensory neurons by protease-activated receptor-2.American journal of physiology. Lung cellular and molecular physiology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Protease-activated receptor 2 (PAR(2)) is involved in airway inflammation and airway hyperresponsiveness; both are the prominent features of asthma. Transient receptor potential vanilloid receptor 1 (TRPV1) is expressed in pulmonary sensory nerves, functions as a thermal and chemical transducer and contributes to neurogenic inflammation. Using cell-attached single-channel recordings we investigated the effect of PAR(2) activation on single TRPV1channel activities in isolated pulmonary sensory neurons. Our immunohistochemical study demonstrated the expression of PAR(2) in rat vagal pulmonary sensory neurons. Our patch clamp study further showed that intracellular application of capsaicin (0.75 microM) induced single channel current that exhibited outward rectification in these neurons. The probability of the channel being open (Po) was significantly increased after the cells were pretreated with PAR2-activating peptide (100 microM, 2 min). Pretreatment with trypsin (0.1 microM, 2 min) also increased the single-channel Po, and the effect was completely inhibited by soybean trypsin inhibitor (0.5 microM, 3 min). In addition, the effect of PAR2 activation was abolished by either U73122 (1 microM, 4 min),a phospholipase C inhibitor, or chelerythrine (10 microM, 4 min), a protein kinase C inhibitor. In conclusion, our data demonstrated that activation of PAR2 upregulated single-channel activitiesofTRPV1and that the effect was mediated through the protein kinase C-dependent transduction pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.