ArticlePlant physiology2009
A redox-mediated modulation of stem bolting in transgenic Nicotiana sylvestris differentially expressing the external mitochondrial NADPH dehydrogenase.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 42 citations in OpenAlex.
- Assessment of Mitochondrial DNA Copy Number, Stability, and Repair in Arabidopsis.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The mitochondrial NADThe Plant journal : for cell and molecular biology · 2019Article
- Suppression of External NADPH Dehydrogenase-NDB1 inInternational journal of molecular sciences · 2018Article
- Improved chloroplast energy balance during water deficit enhances plant growth: more crop per drop.Journal of experimental botany · 2018Article
- Photoperiod Affects the Phenotype of Mitochondrial Complex I Mutants.Plant physiology · 2017Article
- The Ca2+-Regulation of the Mitochondrial External NADPH Dehydrogenase in Plants Is Controlled by Cytosolic pH.PloS one · 2015Article
- Metabolic control of redox and redox control of metabolism in plants.Antioxidants & redox signaling · 2014Review
- Suppression of NDA-type alternative mitochondrial NAD(P)H dehydrogenases in arabidopsis thaliana modifies growth and metabolism, but not high light stimulation of mitochondrial electron transport.Plant & cell physiology · 2014Article
- On the role of plant mitochondrial metabolism and its impact on photosynthesis in both optimal and sub-optimal growth conditions.Photosynthesis research · 2014Review
- The dual targeting ability of type II NAD(P)H dehydrogenases arose early in land plant evolution.BMC plant biology · 2013Article
- NAD⁺ accumulation as a metabolic off switch for orthodox pollen.Plant signaling & behavior · 2013Article
- Alternative oxidase: a mitochondrial respiratory pathway to maintain metabolic and signaling homeostasis during abiotic and biotic stress in plants.International journal of molecular sciences · 2013Review
- Characterization of an internal type-II NADH dehydrogenase from Chlamydomonas reinhardtii mitochondria.Current genetics · 2012Article
- Antisense inhibition of the 2-oxoglutarate dehydrogenase complex in tomato demonstrates its importance for plant respiration and during leaf senescence and fruit maturation.The Plant cell · 2012Article
- Metabolic and miRNA profiling of TMV infected plants reveals biphasic temporal changes.PloS one · 2011Article
- Article
- Molecular identification and functional characterization of Arabidopsis thaliana mitochondrial and chloroplastic NAD+ carrier proteins.The Journal of biological chemistry · 2009Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytosolic NADPH can be directly oxidized by a calcium-dependent NADPH dehydrogenase, NDB1, present in the plant mitochondrial electron transport chain. However, little is known regarding the impact of modified cytosolic NADPH reduction levels on growth and metabolism. Nicotiana sylvestris plants overexpressing potato (Solanum tuberosum) NDB1 displayed early bolting, whereas sense suppression of the same gene led to delayed bolting, with consequential changes in flowering time. The phenotype was dependent on light irradiance but not linked to any change in biomass accumulation. Whereas the leaf NADPH/NADP(+) ratio was unaffected, the stem NADPH/NADP(+) ratio was altered following the genetic modification and strongly correlated with the bolting phenotype. Metabolic profiling of the stem showed that the NADP(H) change affected relatively few, albeit central, metabolites, including 2-oxoglutarate, glutamate, ascorbate, sugars, and hexose-phosphates. Consistent with the phenotype, the modified NDB1 level also affected the expression of putative floral meristem identity genes of the SQUAMOSA and LEAFY types. Further evidence for involvement of the NADPH redox in stem development was seen in the distinct decrease in the stem apex NADPH/NADP(+) ratio during bolting. Additionally, the potato NDB1 protein was specifically detected in mitochondria, and a survey of its abundance in major organs revealed that the highest levels are found in green stems. These results thus strongly suggest that NDB1 in the mitochondrial electron transport chain can, by modifying cell redox levels, specifically affect developmental processes.
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