ArticlePlant physiology2009
FRIGIDA delays flowering in Arabidopsis via a cotranscriptional mechanism involving direct interaction with the nuclear cap-binding complex.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 145 citations in OpenAlex.
- Molecular integration of seasonal temperature signals in flowering time control.Nature reviews. Genetics · 2026Review
- Graded versus ON/OFF control in quantitative gene expression and epigenetic memory.The EMBO journal · 2026Review
- The KH-domain genes FLK and HOS5 integrate flowering and stress responses in Arabidopsis thaliana.Journal of experimental botany · 2025Article
- Role ofInternational journal of molecular sciences · 2025Article
- Comprehensive genome-wide analysis of the GmFRIGIDA gene family in soybean: identification, characterization, and expression dynamics.Frontiers in plant science · 2025Article
- Delineation of loci governing an extra-earliness trait in lentil (Lens culinaris Medik.) using the QTL-Seq approach.Plant biotechnology journal · 2024Article
- Flowering time: From physiology, through genetics to mechanism.Plant physiology · 2024Review
- Identification of vernalization-related genes and cold memory element (CME) required for vernalization response in radish (Raphanus sativus L.).Plant molecular biology · 2024Article
- Article
- Upregulation of tandem duplicated BoFLC1 genes is associated with the non-flowering trait in Brassica oleracea var. capitata.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- VAL1 acts as an assembly platform co-ordinating co-transcriptional repression and chromatin regulation at Arabidopsis FLC.Nature communications · 2022Article
- Phase separation of HRLP regulates flowering time inScience advances · 2022Article
- A Molecular switch for FLOWERING LOCUS C activation determines flowering time in Arabidopsis.The Plant cell · 2022Article
- A premature stop codon in BrFLC2 transcript results in early flowering in oilseed-type Brassica rapa plants.Plant molecular biology · 2022Article
- Differentially Expressed Genes Related to Flowering Transition between Once- and Continuous-Flowering Roses.Biomolecules · 2021Article
- Comparative transcriptomics provides a strategy for phylogenetic analysis and SSR marker development in Chaenomeles.Scientific reports · 2021Article
- Validation of a novel associative transcriptomics pipeline in Brassica oleracea: identifying candidates for vernalisation response.BMC genomics · 2021Article
- Leaf transcriptomic signatures for somatic embryogenesis potential of Elaeis guineensis.Plant cell reports · 2021Article
- Natural temperature fluctuations promoteGenes & development · 2021Article
- Genome sequencing sheds light on the contribution of structural variants to Brassica oleracea diversification.BMC biology · 2021Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
A major determinant of flowering time in natural Arabidopsis (Arabidopsis thaliana) variants is FRIGIDA (FRI). FRI up-regulates expression of the floral repressor FLOWERING LOCUS C (FLC), thereby conferring a vernalization requirement and a winter annual habit. FRI encodes a novel nuclear protein with no conserved domains except for two coiled-coil regions. A mutation in the large subunit of the nuclear cap-binding complex (CBC) suppresses FRI activity, so we have explored the connection between FRI and the nuclear CBC in order to gain further insight into FRI biochemical activity. Mutations in the small subunit of the CBC (CBP20) also suppress FRI up-regulation of FLC. CBP20 interacted directly with FRI in yeast and in planta, and this association of FRI with the 5' cap was reinforced by an RNA ligase-mediated rapid amplification of cDNA ends assay that showed FRI decreased the proportion of FLC transcripts lacking a 5' cap. Loss of CBP20 resulted in very low FLC mRNA levels and an increased proportion of unspliced FLC transcripts. FRI compensated for CBP20 loss, partially restoring FLC levels and normalizing the unspliced-spliced transcript ratio. Our data suggest that FRI up-regulates FLC expression through a cotranscriptional mechanism involving direct physical interaction with the nuclear CBC with concomitant effects on FLC transcription and splicing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.