ArticleApplied and environmental microbiology2009
Staphylococcus aureus virulence expression is impaired by Lactococcus lactis in mixed cultures.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- Fortification of Goat Milk Yogurts with Encapsulated Postbiotic Active Lactococci.Life (Basel, Switzerland) · 2024Article
- Acute toxicity and anti-enterotoxigenic activity of pigment extracted from Micrococcus roseus.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Isolation and Characterization of Staphylococcus aureus from Raw Cow's Milk and Investigating the Effect of Bifidobacterium bifidum Probiotic Cell Free Supernatant on Their Enterotoxins Genes Expression.Archives of Razi Institute · 2023Article
- Lactococcus lactis, a bacterium with probiotic functions and pathogenicity.World journal of microbiology & biotechnology · 2023Review
- Contribution of omics to biopreservation: Toward food microbiome engineering.Frontiers in microbiology · 2022Review
- The impact of Lactococcus lactis (probiotic nasal rinse) co-culture on growth of patient-derived strains of Pseudomonas aeruginosa.International forum of allergy & rhinology · 2020Article
- Inhibitory effect of probiotic yeastIranian journal of microbiology · 2019Article
- The Continuing Threat of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2019Review
- Expression of Staphylococcal Enterotoxins under Stress Encountered during Food Production and Preservation.Toxins · 2017Review
- Anti-Staphylococcal Enterotoxinogenesis ofFood technology and biotechnology · 2017Article
- Article
- Transcriptomic and metabolic responses of Staphylococcus aureus in mixed culture with Lactobacillus plantarum, Streptococcus thermophilus and Enterococcus durans in milk.Journal of industrial microbiology & biotechnology · 2016Article
- Contribution of Lactococcus lactis reducing properties to the downregulation of a major virulence regulator in Staphylococcus aureus, the agr system.Applied and environmental microbiology · 2014Article
- Functional characterization of a Penicillium chrysogenum mutanase gene induced upon co-cultivation with Bacillus subtilis.BMC microbiology · 2014Article
- Genome Sequence of Lactococcus lactis subsp. lactis bv. diacetylactis LD61.Genome announcements · 2014Article
- Discovery of antivirulence agents against methicillin-resistant Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2013Article
- Inhibition of Staphylococcus aureus invasion into bovine mammary epithelial cells by contact with live Lactobacillus casei.Applied and environmental microbiology · 2013Article
- Influence of carvacrol and thymol on the physiological attributes, enterotoxin production and surface characteristics of Staphylococcus aureus strains isolated from foods.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Article
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus is responsible for numerous food poisonings due to the production of enterotoxins by strains contaminating foodstuffs, especially dairy products. Several parameters, including interaction with antagonistic flora such as Lactococcus lactis, a lactic acid bacterium widely used in the dairy industry, can modulate S. aureus proliferation and virulence expression. We developed a dedicated S. aureus microarray to investigate the effect of L. lactis on staphylococcal gene expression in mixed cultures. This microarray was used to establish the transcriptomic profile of S. aureus in mixed cultures with L. lactis in a chemically defined medium held at a constant pH (6.6). Under these conditions, L. lactis hardly affected S. aureus growth. The expression of most genes involved in the cellular machinery, carbohydrate and nitrogen metabolism, and stress responses was only slightly modulated: a short time lag in mixed compared to pure cultures was observed. Interestingly, the induction of several virulence factors and regulators, including the agr locus, sarA, and some enterotoxins, was strongly affected. This work clearly underlines the complexity of L. lactis antagonistic potential for S. aureus and yields promising leads for investigations into nonantibiotic biocontrol of this major pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.