ArticleApplied and environmental microbiology2009
Recombination between homoeologous chromosomes of lager yeasts leads to loss of function of the hybrid GPH1 gene.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Forty new genomes shed light on sexual reproduction and the origin of tetraploidy in Microsporidia.PLoS biology · 2025Article
- Whole Genome Sequencing,G3 (Bethesda, Md.) · 2018Article
- Genome annotation of a Saccharomyces sp. lager brewer's yeast.Genomics data · 2016Article
- Chromosomal Copy Number Variation in Saccharomyces pastorianus Is Evidence for Extensive Genome Dynamics in Industrial Lager Brewing Strains.Applied and environmental microbiology · 2015Article
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- Recurrent rearrangement during adaptive evolution in an interspecific yeast hybrid suggests a model for rapid introgression.PLoS genetics · 2013Article
- Evolutionary role of interspecies hybridization and genetic exchanges in yeasts.Microbiology and molecular biology reviews : MMBR · 2012Review
- Polyploidy in fungi: evolution after whole-genome duplication.Proceedings. Biological sciences · 2012Review
- Yeast evolutionary genomics.Nature reviews. Genetics · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yeasts used in the production of lagers contain complex allopolyploid genomes, resulting from the fusion of two different yeast species closely related to Saccharomyces cerevisiae and Saccharomyces bayanus. Recombination between the homoeologous chromosomes has generated a number of hybrid chromosomes. These recombination events provide potential for adaptive evolution through the loss or gain of gene function. We have examined the genotypic and phenotypic effects of one of the conserved recombination events that occurred on chromosome XVI in the region of YPR159W and YPR160W. Our analysis shows that the recombination event occurred within the YPR160W gene, which encodes the enzyme glycogen phosphorylase and generates a hybrid gene that does not produce mature mRNA and is nonfunctional due to frameshifts in the coding region. The loss of function of the hybrid gene leads to glycogen levels similar to those found in haploid yeast strains. The implications for the control of glycogen levels in fermentative yeasts are discussed.
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