ArticleRespiratory physiology & neurobiology2009
Effects of baroreceptor activation on respiratory variability in rat.
Article in Respiratory physiology & neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- Analysis of the effect of 6-Hz binaural beats on electroencephalographic and autonomic parameters of healthy individuals: An exploratory study.Physiological reports · 2025Article
- Ventilatory response to head-down-tilt in healthy human subjects.Experimental physiology · 2024Article
- Dynamics of ventilatory pattern variability and Cardioventilatory Coupling during systemic inflammation in rats.Frontiers in network physiology · 2023Article
- Confounding effects of heart rate, breathing rate, and frontal fNIRS on interoception.Scientific reports · 2022Article
- Vasopressin and Breathing: Review of Evidence for Respiratory Effects of the Antidiuretic Hormone.Frontiers in physiology · 2021Review
- Blood pressure drives multispectral tuning of inspiration via a linked-loop neural network.Journal of neurophysiology · 2020Article
- Vascular control of the COeLife · 2020Article
- Hypothalamic PVN contributes to acute intermittent hypoxia-induced sympathetic but not phrenic long-term facilitation.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Kölliker-Fuse nuclei regulate respiratory rhythm variability via a gain-control mechanism.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Haemodynamic Responses to Selective Vagal Nerve Stimulation under Enalapril Medication in Rats.PloS one · 2016Article
- Cardiorespiratory coupling: common rhythms in cardiac, sympathetic, and respiratory activities.Progress in brain research · 2014Review
- PACAP causes PAC1/VPAC2 receptor mediated hypertension and sympathoexcitation in normal and hypertensive rats.American journal of physiology. Heart and circulatory physiology · 2012Article
- Computational models and emergent properties of respiratory neural networks.Comprehensive Physiology · 2012Review
- Cardio-ventilatory coupling in young healthy resting subjects.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Ventilatory chaos is impaired in carotid atherosclerosis.PloS one · 2011Article
- Protective effect of the daming capsule on impaired baroreflexes in STZ-induced diabetic rats with hyperlipoidemia.BMC complementary and alternative medicine · 2010Article
- Effect of baroreceptor stimulation on the respiratory pattern: insights into respiratory-sympathetic interactions.Respiratory physiology & neurobiology · 2010Article
- Impairment of the baroreflex control of human respiratory resistance with age.European journal of medical research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Controversy surrounds the respiratory responses to baroreceptor activation. Although many reflexes that effect respiration (e.g. chemoreflexes and nociceptive reflexes) frequently affect cardiovascular parameters, the effect of baroreflex stimulation within normal physiological limits is generally considered to affect only blood pressure and heart rate. Even though previous authors have reported that baroreceptor activation can affect respiratory activity, the effects on respiratory frequency and amplitude are highly variable, and changes in perfusion evoked by blood pressure manipulation could account for the observed effects. Here, we determined the respiratory effects of activating arterial baroreceptors by intravenous injection of phenylephrine or angiotensin II, or by electrical stimulation of the aortic depressor nerve (ADN). In urethane-anesthetized vagotomized rats, 1, 2 and 4s trains of tetanic ADN stimulation evoked 3.1+/-1.1%, 11.2+/-13.6% and 21.9+/-8.9% increases in inspiratory (TI) time and 26.5+/-18%, 23.4+/-15.7% and 34.6+/-20.9% increases in expiratory (TE) time, respectively (P<0.05 in both cases), but no effect on the amplitude of bursts recorded in the phrenic nerve. Similar effects were observed following pressor trials evoked by intravenous PE (TE: +26.1+/-9.1%, P<0.01), but not Ang II. Intermittent ADN stimulation (single pulse, 1 Hz) significantly increased the variability of TI during periods of low respiratory drive (P<0.05) without significantly affecting any other parameters. We propose that a specific baroreceptor-respiratory response exists that is independent of changes in blood flow. In contrast to the effects of baroreceptor stimulation on sympathetic nerve activity, the baro-respiratory response is subtle and highly dependent on respiratory drive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.