ArticleReproductive toxicology (Elmsford, N.Y.)2009
The effect of fetal and neonatal nicotine exposure on renal development of AT(1) and AT(2) receptors.
Article in Reproductive toxicology (Elmsford, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Prenatal Cannabis and Tobacco: Studies in Animal Models.Advances in experimental medicine and biology · 2026Review
- Smoking Enigma in Coronavirus Disease 2019: A Tug of War between Predisposition and Possible Way Out.Tobacco use insights · 2021Article
- Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population?The FEBS journal · 2020Review
- Heat or Burn? Impacts of Intrauterine Tobacco Smoke and E-Cigarette Vapor Exposure on the Offspring's Health Outcome.Toxics · 2018Review
- The effect of resveratrol on angiotensin II levels and the rate of transcription of its receptors in the rat cardiac hypertrophy model.The journal of physiological sciences : JPS · 2017Article
- Developmental cigarette smoke exposure II: Kidney proteome profile alterations in 6 month old adult offspring.Reproductive toxicology (Elmsford, N.Y.) · 2016Article
- Gender differences in developmental programming of cardiovascular diseases.Clinical science (London, England : 1979) · 2016Review
- Chronic hypoxia in pregnancy affected vascular tone of renal interlobar arteries in the offspring.Scientific reports · 2015Article
- Fibronectin regulation by vitamin C treatment in kidneys of nicotinic mice offspring.Iranian Red Crescent medical journal · 2014Article
- Perinatal nicotine exposure increases angiotensin II receptor-mediated vascular contractility in adult offspring.PloS one · 2014Article
- Fetal hypoxia results in programming of aberrant angiotensin ii receptor expression patterns and kidney development.International journal of medical sciences · 2013Article
- Fetal stress and programming of hypoxic/ischemic-sensitive phenotype in the neonatal brain: mechanisms and possible interventions.Progress in neurobiology · 2012Review
- Maternal smoking during pregnancy and kidney volume in the offspring: the Generation R Study.Pediatric nephrology (Berlin, Germany) · 2011Article
- Altered dipsogenic responses and expression of angiotensin receptors in the offspring exposed to prenatal high sucrose.Peptides · 2011Article
- Long-term consequences of fetal and neonatal nicotine exposure: a critical review.Toxicological sciences : an official journal of the Society of Toxicology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
aimsMaternal cigarette smoking accompanied with fetal and neonatal growth restriction causes abnormalities in organ development in the postnatal life. The present study determined the effect of maternal administration of nicotine on the development of the kidney in rats by examining the expression of renal angiotensin II receptors at mRNA and protein levels as well as kidney weight during postnatal development.
methodsNicotine was administered to pregnant rats via subcutaneous osmotic minipumps throughout gestation and up to 10 days after delivery. Kidneys were removed and collected from both male and female offspring at ages of 14-day-old, 30-day-old, and 5-month-old. Maternal nicotine administration significantly reduced renal AT(2) receptor (AT(2)R) mRNA and protein abundance in both males and females at all three developmental ages examined.
resultsAlthough AT(1) receptor (AT(1)R) mRNA and protein levels were not significantly changed between the control offspring and the offspring exposed to maternal nicotine during the early developmental period, the renal AT(1)R/AT(2)R ratio was significantly increased. This was associated with a significant decrease of kidney weight in both male and female offspring.
conclusionsThe results demonstrated that the development of renal angiotensin II receptor could be changed following exposure to perinatal nicotine, and such change in the kidney could be long-term in postnatal life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.