ArticleJournal of ethnopharmacology2009
Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation.
Article in Journal of ethnopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Huo-Luo-Xiao-Ling (HLXL)-Dan, a Traditional Chinese Medicine, for patients with osteoarthritis of the knee: a multi-site, randomized, double-blind, placebo-controlled phase II clinical trial.Osteoarthritis and cartilage · 2015Trial
- Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway.Scientific reports · 2015Article
- A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis.Drug design, development and therapy · 2015Article
- Inhibition of adjuvant-induced arthritis by nasal administration of novel synthetic peptides from heat shock protein 65.BMC musculoskeletal disorders · 2014Article
- Microarray analysis reveals the molecular basis of antiarthritic activity of huo-luo-xiao-ling dan.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Mediators of inflammation-induced bone damage in arthritis and their control by herbal products.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Immunomodulation of Autoimmune Arthritis by Herbal CAM.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Suppression of ongoing experimental arthritis by a chinese herbal formula (huo-luo-xiao-ling dan) involves changes in antigen-induced immunological and biochemical mediators of inflammation.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Article
- In vivo anti-inflammatory and antiarthritic activities of aqueous extracts from Thymelaea hirsuta.Pharmacognosy researchArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
ethnopharmacological relevanceHLXL is a traditional Chinese medicine that has long been used in folk medicine for the treatment of chronic inflammatory diseases. However, the precise immunological mechanisms by which HLXL mediates its anti-inflammatory activity are not fully defined. AIM OF THE STUDY: To determine the effects of HLXL on antigen-specific immune parameters in adjuvant-induced inflammation model in the Lewis rat. MATERIALS AND
methodsRats were fed daily with either HLXL (2.3g/kg) or vehicle (water) beginning 3 days before subcutaneous injection of heat-killed Mycobacterium tuberculosis H37Ra (Mtb), and then continued for another 6 days. After 9 days of Mtb injection, the draining lymph node cells were tested for T cell proliferative and cytokine responses against mycobacterial heat-shock protein 65 (Bhsp65). Moreover, sera were tested for anti-Bhsp65 antibodies and nitric oxide (NO).
resultsHLXL-treated rats showed reduced T cell proliferative response to Bhsp65 compared to control rats. Furthermore, HLXL suppressed IL-17 response but enhanced IL-10 response without much effect on IFN-gamma. HLXL treatment also reduced the levels of anti-Bhsp65 antibodies but not that of NO.
conclusionsHLXL feeding modulated both the cellular and the humoral immune response to Bhsp65 favoring an anti-inflammatory milieu for the suppression of adjuvant-induced inflammation.
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