ArticleNeurotoxicology2009
Variations at a quantitative trait locus (QTL) affect development of behavior in lead-exposed Drosophila melanogaster.
Article in Neurotoxicology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science.Current protocols · 2023Review
- Pre-adult exposure to three heavy metals leads to changes in the head transcriptome of adult flies.microPublication biology · 2022Article
- Experimental Protocol for Using Drosophila As an Invertebrate Model System for Toxicity Testing in the Laboratory.Journal of visualized experiments : JoVE · 2018Article
- Article
- Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity.International journal of molecular sciences · 2017Review
- A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure.PLoS genetics · 2017Article
- Asymmetrical positive assortative mating induced by developmental lead (PbCurrent zoology · 2017Article
- Identification of Splicing Quantitative Trait Loci (sQTL) inFrontiers in genetics · 2017Article
- The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster.Environmental health perspectives · 2016Article
- LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway.Cellular and molecular neurobiology · 2013Article
- Drosophila melanogaster as a model for lead neurotoxicology and toxicogenomics research.Frontiers in genetics · 2012Article
- Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead.Neurotoxicology · 2009Article
- Chronic lead exposure alters presynaptic calcium regulation and synaptic facilitation in Drosophila larvae.Neurotoxicology · 2009Article
- Genetic aspects of behavioral neurotoxicology.Neurotoxicology · 2009Article
- Drosophotoxicology: the growing potential for Drosophila in neurotoxicology.Neurotoxicology and teratologyReview
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
We developed Drosophila melanogaster as a model to study correlated behavioral, neuronal and genetic effects of the neurotoxin lead, known to affect cognitive and behavioral development in children. We showed that, as in vertebrates, lead affects both synaptic development and complex behaviors (courtship, fecundity, locomotor activity) in Drosophila. By assessing differential behavioral responses to developmental lead exposure among recombinant inbred Drosophila lines (RI), derived from parental lines Oregon R and Russian 2b, we have now identified a genotype by environment interaction (GEI) for a behavioral trait affected by lead. Drosophila Activity Monitors (TriKinetics, Waltham, MA), which measure activity by counting the number of times a single fly in a small glass tube walks through an infrared beam aimed at the middle of the tube, were used to measure activity of flies, reared from eggs to 4 days of adult age on either control or lead-contaminated medium, from each of 75 RI lines. We observed a significant statistical association between the effect of lead on Average Daytime Activity (ADA) across lines and one marker locus, 30AB, on chromosome 2; we define this as a Quantitative Trait Locus (QTL) associated with behavioral effects of developmental lead exposure. When 30AB was from Russian 2b, lead significantly increased locomotor activity, whereas, when 30AB was from Oregon R, lead decreased it. 30AB contains about 125 genes among which are likely "candidate genes" for the observed lead-dependent behavioral changes. Drosophila are thus a useful, underutilized model for studying behavioral, synaptic and genetic changes following chronic exposure to lead or other neurotoxins during development.
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