ReviewNeuroscience and biobehavioral reviews2009
Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide.
Review in Neuroscience and biobehavioral reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 197 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influenza Challenge in Mood Disorders
Prospective Study to Quantify the Change in Weight at a Pneumonia
Who cites it
197 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Multi-trait analysis for genome-wide association study of five psychiatric disorders.Translational psychiatry · 2020Pooled it
- Biological markers in noninvasive brain stimulation trials in major depressive disorder: a systematic review.The journal of ECT · 2014Pooled it
- Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD.Journal of psychiatry & neuroscience : JPN · 2013Pooled it
- A meta-analysis of functional neuroimaging studies of self- and other judgments reveals a spatial gradient for mentalizing in medial prefrontal cortex.Journal of cognitive neuroscience · 2012Pooled it
- Changes in brain functional networks in remitted major depressive disorder: a six-month follow-up study.BMC psychiatry · 2023Trial
- Neural correlates of rapid antidepressant response to ketamine in bipolar disorder.Bipolar disorders · 2014Trial
- Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: a pilot fMRI study.Psychiatry research · 2013Trial
- Baseline brain metabolism in resistant depression and response to transcranial magnetic stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- Impact of Short-term Rehabilitation on Chronic Stress-induced Brain Alterations and Associated Cognitive Deficits.Annals of neurosciences · 2026Article
- Changes in kynurenine pathway metabolites and brain structure in response to behavioral activation therapy.Brain, behavior, and immunity · 2026Article
- Shared subcortical-default mode morphological dysconnectivity in adolescent bipolar disorder, major depressive disorder and schizophrenia.Communications biology · 2026Article
- A High-Accuracy and Easy-Use Differential Diagnosis Method of Bipolar Disorder Depressive Phase and Major Depressive Disorder Using a Wearable Near-Infrared Spectroscopy.Bipolar disorders · 2026Article
- Differences in the Efficacy of Cognitive Function Treatment Related to Functional Patterns in the Frontal-Limbic Network in Patients With Bipolar Disorder.CNS neuroscience & therapeutics · 2026Article
- Exploring the relationship between prefrontal cortex activation, standing balance, and fatigue in people post-stroke: A fNIRS study.NeuroRehabilitation · 2025Article
- Novel Insights into Dietary Bioactive Compounds and Major Depressive Disorders: Evidence from Animal Studies and Future Perspectives.The Journal of nutrition · 2025Review
- Altered synaptic homeostasis: a key factor in the pathophysiology of depression.Cell & bioscience · 2025Review
- Alterations of Adult Prefrontal Circuits Induced by Early Postnatal Fluoxetine Treatment Mediated by 5-HT7 Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Kynurenine Metabolism is Associated with Antidepressant Response to Selective Serotonin Reuptake Inhibitors.bioRxiv : the preprint server for biology · 2025Article
- Molecular genetic basis of the primary emotions in young adults: an exploratory analysis of genetic polymorphisms across dopamine, serotonin, oxytocin, endogenous opioid, and neurotrophic factor pathways.Frontiers in pharmacology · 2025Article
- Possible antidepressant mechanism of acupuncture: targeting neuroplasticity.Frontiers in neuroscience · 2025Review
137 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Both major depressive disorder and bipolar disorder are the subject of a voluminous imaging and genetics literature. Here, we attempt a comprehensive review of MRI and metabolic PET studies conducted to date on these two disorders, and interpret our findings from the perspective of developmental and degenerative models of illness. Elevated activity and volume loss of the hippocampus, orbital and ventral prefrontal cortex are recurrent themes in the literature. In contrast, dorsal aspects of the PFC tend to display hypometabolism. Ventriculomegaly and white matter hyperintensities are intimately associated with depression in elderly populations and likely have a vascular origin. Important confounding influences are medication, phenotypic and genetic heterogeneity, and technological limitations. We suggest that environmental stress and genetic risk variants interact with each other in a complex manner to alter neural circuitry and precipitate illness. Imaging genetic approaches hold out promise for advancing our understanding of affective illness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.