ArticleClinical immunology (Orlando, Fla.)2009
Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes.
Article in Clinical immunology (Orlando, Fla.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- The MHC in the era of next-generation sequencing: Implications for bridging structure with function.Human immunology · 2019Review
- Homozygosity disequilibrium associated with treatment response and its methylation regulation.BMC proceedings · 2018Article
- Role of major histocompatibility complex variation in graft-versus-host disease after hematopoietic cell transplantation.F1000Research · 2017Review
- Protective effect of HLA-DQB1 alleles against alloimmunization in patients with sickle cell disease.Human immunology · 2016Article
- Dominant sequences of human major histocompatibility complex conserved extended haplotypes from HLA-DQA2 to DAXX.PLoS genetics · 2014Article
- Analysis of homozygosity disequilibrium using whole-genome sequencing data.BMC proceedings · 2014Article
- Significance of ethnicity in the risk of acute graft-versus-host disease and leukemia relapse after unrelated donor hematopoietic stem cell transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2013Article
- The next big idea.Diabetes technology & therapeutics · 2013Article
- Genetics of graft-versus-host disease: the major histocompatibility complex.Blood reviews · 2013Review
- Article
- Congruence as a measurement of extended haplotype structure across the genome.Journal of translational medicine · 2012Article
- Genotyping of single nucleotide polymorphisms by 5' nuclease allelic discrimination.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Article
- HLA and celiac disease susceptibility: new genetic factors bring open questions about the HLA influence and gene-dosage effects.PloS one · 2012Article
- Article
- Dominant suppression of Addison's disease associated with HLA-B15.The Journal of clinical endocrinology and metabolism · 2011Article
- The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes.Diabetologia · 2011Article
- Haplotype analysis discriminates genetic risk for DR3-associated endocrine autoimmunity and helps define extreme risk for Addison's disease.The Journal of clinical endocrinology and metabolism · 2010Article
- Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes.Diabetes · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The availability of both HLA data and genotypes for thousands of SNPs across the major histocompatibility complex (MHC) in 1240 complete families of the Type 1 Diabetes Genetics Consortium allowed us to analyze the occurrence and extent of megabase contiguous identity for founder chromosomes from unrelated individuals. We identified 82 HLA-defined haplotype groups, and within these groups, megabase regions of SNP identity were readily apparent. The conserved chromosomes within the 82 haplotype groups comprise approximately one third of the founder chromosomes. It is currently unknown whether such frequent conservation for groups of unrelated individuals is specific to the MHC, or if initial binning by highly polymorphic HLA alleles facilitated detection of a more general phenomenon within the MHC. Such common identity, specifically across the MHC, impacts type 1 diabetes susceptibility and may impact transplantation between unrelated individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.