Evidence map›Paper›PMID 19426807›Full record

ReviewMethods (San Diego, Calif.)2009

Single molecule transcription elongation.

Eric A Galburt, Stephan W Grill, Carlos Bustamante

Abstract readReview
In one paragraph

Review in Methods (San Diego, Calif.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Single-Molecule Techniques to Study Chromatin.Frontiers in cell and developmental biology · 2021
    Review
  3. DNA replication:Computational and structural biotechnology journal · 2021
    Review
  4. A review on nonlinear DNA physics.Royal Society open science · 2020
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observing Single RNA Polymerase Molecules Down to Base-Pair Resolution.Methods in molecular biology (Clifton, N.J.) · 2017
    Article
  10. Nucleosomal arrangement affects single-molecule transcription dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  11. Mechanisms of backtrack recovery by RNA polymerases I and II.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eric A GalburtMax Planck Institute for the Physics of Complex Systems, Nöthnitzerstrasse 38, 01187 Dresden, Germany. egalburt@biochem.wustl.edu
Stephan W Grill
Carlos Bustamante

Funding

THE PHYSICAL CHEMISTRY OF NUCLEIC ACIDSR01GM032543 · NIGMS · UNIVERSITY OF OREGON · PI CARLOS Jose BUSTAMANTE · 1985 to 2026
$6.4M
PHYSICAL CHEMISTRY OF NUCLEIC ACIDSR37GM032543 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BUSTAMANTE, CARLOS JOSE · 1999 to 2008
$2.4M
NIGMS NIH HHS R01 GM032543NIGMS NIH HHS R37 GM032543
6 · The paper itself

Abstract

Single molecule optical trapping assays have now been applied to a great number of macromolecular systems including DNA, RNA, cargo motors, restriction enzymes, DNA helicases, chromosome remodelers, DNA polymerases and both viral and bacterial RNA polymerases. The advantages of the technique are the ability to observe dynamic, unsynchronized molecular processes, to determine the distributions of experimental quantities and to apply force to the system while monitoring the response over time. Here, we describe the application of these powerful techniques to study the dynamics of transcription elongation by RNA polymerase II from Saccharomyces cerevisiae.

Indexed as

Optics and PhotonicsRNA Polymerase IITranscriptional Elongation FactorsTranscription, GeneticMolecular BiologyRNA Polymerase IITranscriptional Elongation Factors

Identifiers

PMID19426807
PMCPMC2767109

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.