ArticleEuropean journal of pharmacology2009
Chronic stress differentially regulates cannabinoid CB1 receptor binding in distinct hippocampal subfields.
Article in European journal of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Individual and additive effects of childhood maltreatment and substance use disorder histories on baseline and stress-induced changes in peripheral stress biomarkers.Psychopharmacology · 2026Article
- Increasing CB2 Receptor Activity after Early Life Stress Prevents Depressive Behavior in Female Rats.Biomolecules · 2024Article
- Sex-Specific Differences and the Role of Environmental Enrichment in the Expression of Hippocampal CBBrain sciences · 2024Article
- Influence of early-life stress on hippocampal synaptic and network properties.Frontiers in neural circuits · 2024Review
- The neuropharmacology of cannabinoid receptor ligands in central signaling pathways.The European journal of neuroscience · 2022Review
- Innovative Clinical-Organizational Model to Ensure Appropriateness and Quality in the Management of Medical Cannabis: An Italian Regional Case.Healthcare (Basel, Switzerland) · 2021Article
- In Vivo Availability of Cannabinoid 1 Receptor Levels in Patients With First-Episode Psychosis.JAMA psychiatry · 2019Article
- Involvement of Nrf2 in development of anxiety-like behavior by linking Bcl2 to oxidative phosphorylation: estimation in rat hippocampus, amygdala, and prefrontal cortex.Journal of molecular neuroscience : MN · 2015Article
- Stress regulates endocannabinoid-CB1 receptor signaling.Seminars in immunology · 2014Review
- Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures.Neurotoxicity research · 2014Article
- Article
- Repeated stress impairs endocannabinoid signaling in the paraventricular nucleus of the hypothalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Sexually-dimorphic alterations in cannabinoid receptor density depend upon prenatal/early postnatal history.Neurotoxicology and teratologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to chronic stress has been found to decrease cannabinoid CB(1) receptor expression in the hippocampus; however, the specificity of this phenomenon to specific subfields of the hippocampus has not been characterized. To this extent, male Sprague-Dawley rats were exposed to 21 days of restraint stress (6 h/day), after which autoradiographical analysis of cannabinoid CB(1) receptor binding site densities were examined in the CA1, CA3 and dentate gyrus subfields of the hippocampus. Chronic stress was found to produce a significant reduction in cannabinoid CB(1) receptor binding in the dentate gyrus, while increasing cannabinoid CB(1) receptor binding in the CA3. There was no effect of chronic stress on cannabinoid CB(1) receptor binding in the CA1, or two other proximal regions, the retrosplenial cortical gyrus and the laterodorsal thalamus. Given the role of hippocampal cannabinoid CB(1) receptor activity in the maintenance of synaptic integrity and neuroplasticity in the hippocampus, these data suggest that changes in cannabinoid CB(1) receptor activity following stress may contribute to stress-induced modulation of these processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.