ArticleVascular
Hemodynamically driven vein graft remodeling: a systems biology approach.
Article in Vascular. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Beyond CFD: Emerging methodologies for predictive simulation in cardiovascular health and disease.Biophysics reviews · 2023Review
- The Role of Immunomodulation in Vein Graft Remodeling and Failure.Journal of cardiovascular translational research · 2021Review
- A versatile hybrid agent-based, particle and partial differential equations method to analyze vascular adaptation.Biomechanics and modeling in mechanobiology · 2019Article
- Hemodynamic Influence on Smooth Muscle Cell Kinetics and Phenotype During Early Vein Graft Adaptation.Annals of biomedical engineering · 2017Article
- Linking gene dynamics to vascular hyperplasia - Toward a predictive model of vein graft adaptation.PloS one · 2017Article
- Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention.Annals of biomedical engineering · 2016Article
- Diet-induced obesity drives negative mouse vein graft wall remodeling.Journal of vascular surgery · 2014Article
- A dynamical system that describes vein graft adaptation and failure.Journal of theoretical biology · 2013Article
- Rule-based model of vein graft remodeling.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Despite intense investigation over several decades to understand the mechanisms of vein graft failure, few therapeutic modalities have emerged. Emphasis using standard reductionist approaches has been focused on cataloging the components involved in the early events following vein graft implantation, but limited insight has been gained in understanding the dynamic interaction of these components. We propose that the application of systems theory offers the opportunity for significant advances in this area. Focused on modeling the dynamic relationships that define living organisms, systems biology provides the necessary tools to further our understanding of the complex series of overlapping biologic events on surgical implantation of the vein graft. Through the use of ordinary differential equation and agent-based modeling techniques, we present our ongoing efforts to define the nonlinear interactions between hemodynamics and vascular adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.