ArticleBMC neuroscience2009
The genetic control of neocortex volume and covariation with neocortical gene expression in mice.
Article in BMC neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Investigating Motor Coordination Using BXD Recombinant Inbred Mice to Model the Genetic Underpinnings of Developmental Coordination Disorder.Genes, brain, and behavior · 2025Article
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- Shaping vulnerability to addiction - the contribution of behavior, neural circuits and molecular mechanisms.Neuroscience and biobehavioral reviews · 2018Review
- Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice.Scientific reports · 2017Article
- Dissociation of spontaneous seizures and brainstem seizure thresholds in mice exposed to eight flurothyl-induced generalized seizures.Epilepsia open · 2017Article
- Self-Confirmation and Ascertainment of the Candidate Genomic Regions of Complex Trait Loci - A None-Experimental Solution.PloS one · 2016Article
- Genetics of gene expression in CNS.International review of neurobiology · 2014Review
- Limitation of number of strains and persistence of false positive loci in QTL mapping using recombinant inbred strains.PloS one · 2014Article
- Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli.Nature biotechnology · 2013Article
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- A promoter polymorphism in the Per3 gene is associated with alcohol and stress response.Translational psychiatry · 2012Article
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- Candidate genes in ocular dominance plasticity.Frontiers in neuroscience · 2012Article
- Genetic, morphometric, and behavioral factors linked to the midsagittal area of the corpus callosum.Frontiers in genetics · 2012Article
- Genetic architecture supports mosaic brain evolution and independent brain-body size regulation.Nature communications · 2012Article
- Natural and engineered coding variation in antidepressant-sensitive serotonin transporters.Neuroscience · 2011Article
- Genetic dissection of behavioral flexibility: reversal learning in mice.Biological psychiatry · 2011Article
- Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures.Respiratory research · 2011Article
- Article
- Updated neuronal scaling rules for the brains of Glires (rodents/lagomorphs).Brain, behavior and evolution · 2011Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe size of the cerebral cortex varies widely within human populations, and a large portion of this variance is modulated by genetic factors. The discovery and characterization of these genes and their variants can contribute to an understanding of individual differences in brain development, behavior, and disease susceptibility. Here we use unbiased stereological techniques to map quantitative trait loci (QTLs) that modulate the volume of neocortex.
resultsWe estimated volumes bilaterally in an expanded set of BXD recombinant inbred strains (n = 56 strains and 223 animals) taken from the Mouse Brain Library http://www.mbl.org. We generated matched microarray data for the cerebral cortex in the same large panel of strains and in parental neonates to efficiently nominate and evaluate candidate genes. Volume of the neocortex varies widely, and is a heritable trait. Genome-wide mapping of this trait revealed two QTLs--one on chromosome (Chr) 6 at 88 +/- 5 Mb and another at Chr 11 (41 +/- 8 Mb). We generated both neonatal and adult neocortical gene expression databases using microarray technology. Using these databases in combination with other bioinformatic tools we have identified positional candidates on these QTL intervals.
conclusionThis study is the first to use the expanded set of BXD strains to map neocortical volume, and we found that normal variation of this trait is, at least in part, genetically modulated. These results provide a baseline from which to assess the genetic contribution to regional variation in neocortical volume, as well as other neuroanatomic phenotypes that may contribute to variation in regional volume, such as proliferation, death, and number and packing density of neurons.
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