ArticleAlcoholism, clinical and experimental research2009
Associations among GABRG1, level of response to alcohol, and drinking behaviors.
Article in Alcoholism, clinical and experimental research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Common variants in HLA-DRA gene are associated with alcohol dependence in two Caucasian samples.Journal of molecular neuroscience : MN · 2013Pooled it
- Effects of naltrexone on neural and subjective response to alcohol in treatment-seeking alcohol-dependent patients.Alcoholism, clinical and experimental research · 2014Trial
- Voluntary intravenous self-administration of alcohol detects an interaction between GABAergic manipulation and GABRG1 polymorphism genotype: a pilot study.Alcoholism, clinical and experimental research · 2013Trial
- Multi-omics and electrophysiological examination of GABAMolecular psychiatry · 2026Article
- Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample.Risk management and healthcare policy · 2025Article
- Sex differences in GABAGenes, brain, and behavior · 2022Article
- Cross-sectional and prospective associations of drinking characteristics with scores from the Self-Report of the Effects of Alcohol questionnaire and findings from alcohol challenges.Alcoholism, clinical and experimental research · 2021Article
- GABAPsychopharmacology · 2018Review
- A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.Alcoholism, clinical and experimental research · 2018Review
- Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models.Pharmacogenomics · 2017Review
- Experimental psychopathology paradigms for alcohol use disorders: Applications for translational research.Behaviour research and therapy · 2016Review
- Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking.Alcoholism, clinical and experimental research · 2015Article
- Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.BMC systems biology · 2015Article
- Selection for drinking in the dark alters brain gene coexpression networks.Alcoholism, clinical and experimental research · 2013Article
- Effect of homozygous deletions at 22q13.1 on alcohol dependence severity and cue-elicited BOLD response in the precuneus.Addiction biology · 2013Article
- Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire.Drug and alcohol dependence · 2013Article
- GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects.Archives of medical science : AMS · 2012Article
- Review of biological mechanisms and pharmacological treatments of comorbid PTSD and substance use disorder.Neuropharmacology · 2012Review
- The genetics of substance dependence.Annual review of genomics and human genetics · 2012Review
- Transcriptome-wide survey of mouse CNS-derived cells reveals monoallelic expression within novel gene families.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecent studies of the genetics of alcoholism have focused on a cluster of genes encoding for gamma-aminobutyric acid (GABA(A)) receptor subunits, which is thought to play a role in the expression of addiction phenotypes. This study examined allelic associations between 2 single nucleotide polymorphisms (SNPs) of the GABRG1 gene (rs1391166 and rs1497571) and alcohol phenotypes, namely level of response to alcohol, alcohol use patterns, and alcohol-related problems.
methodParticipants were non-treatment-seeking seeking hazardous drinkers (n = 124) who provided DNA samples, participated in a face-to-face interview for level of response to alcohol, and completed a series of drinking and individual differences measures.
resultsAnalyses revealed that a SNP of the GABRG1 gene (rs1497571) was associated with level of response to alcohol and drinking patterns in this subclinical sample. Follow-up mediational analyses were also conducted to examine putative mechanisms underlying these associations. DISCUSSION: These findings replicate and extend recent research suggesting that genetic variation at the GABRG1 locus may underlie the expression of alcohol phenotypes, including level of response to alcohol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.