Evidence map›Paper›PMID 19425026›Full record

ArticleAngewandte Chemie (International ed. in English)2009

Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery.

Zhaohua Huang, Mahmoud Reza Jaafari, Francis C Szoka

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Novel Lipid-Based Carriers of Provitamin DMolecules (Basel, Switzerland) · 2024
    Article
  3. Review
  4. Article
  5. Halimanes and cancer:Frontiers in chemistry · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Biodistribution andAntimicrobial agents and chemotherapy · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhaohua HuangDepartment of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, CA 94143-0912, USA.
Mahmoud Reza Jaafari
Francis C Szoka

Funding

"Smart" Nanoparticles for Cancer Therapy and ImagingU54CA119343 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI VAN DYKE, TERRY A · 2005 to 2009
$18.3M
Targeted Drug Delivery to Surface Receptors.R01GM061851 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SZOKA, FRANCIS C. · 2001 to 2015
$3.5M
Rational Design of Viral-Mimetic Lipid Gene VectorsR01EB003008 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SZOKA, FRANCIS C. · 2003 to 2013
$3.2M
NCI NIH HHS CA119343NCI NIH HHS U54 CA119343NIBIB NIH HHS EB003008NIBIB NIH HHS R01 EB003008NIGMS NIH HHS GM61851NIGMS NIH HHS R01 GM061851
6 · The paper itself

Abstract

Extreme makeover of cholesterol: Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer-stabilizing effect of free cholesterol but prevents its transfer from the bilayer. Thus, disterolphospholipids (e.g. 1) are valuable new components for liposome formulation.

Indexed as

Drug Delivery SystemsAnimalsAntibiotics, AntineoplasticDoxorubicinLiposomesMiceMice, Inbred BALB CMolecular StructurePhospholipidsAntibiotics, AntineoplasticDoxorubicinLiposomesPhospholipids

Identifiers

PMID19425026
PMCPMC2773798

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.