ArticleAge (Dordrecht, Netherlands)2008
Design of aging intervention studies: the NIA interventions testing program.
Article in Age (Dordrecht, Netherlands), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed.
- Rapamycin enhances BCG-specific γδ T cells during intravesical BCG therapy for non-muscle invasive bladder cancer: a randomized, double-blind study.Journal for immunotherapy of cancer · 2021Trial
- Frailty assessment in naturally aged mouse models: classification, limitations, and future directions.GeroScience · 2026Review
- Sex differences in response to longevity interventions.Ageing research reviews · 2026Review
- Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice.GeroScience · 2026Article
- Acarbose improves cognitive function in a mouse model of normal aging but not Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Statistical Methods in Aging Research: Improving Current Practices and Embracing Emerging Approaches.Annual review of statistics and its application · 2026Article
- Anti-senescence Effects of Nanovesicles Derived from Cluster of Differentiation-146-Positive Tonsil Mesenchymal Stem Cells via Modulation of the Tumor Protein 53 Pathway.Biomaterials research · 2026Article
- Emerging uncertainty on the anti-aging potential of metformin.Ageing research reviews · 2025Review
- Time to Consider Pharmacologic Management of Unruptured Intracranial Aneurysms?Journal of stroke · 2025Review
- Article
- The impact of co-housing on murine aging studies.GeroScience · 2025Article
- Ginkgolide B increases healthspan and lifespan of female mice.Nature aging · 2025Article
- Anti-aging properties of the aminosterols of the dogfish shark.npj aging · 2024Review
- Article
- Rapamycin Reduces Carcinogenesis and Enhances Survival in Mice when Administered after Nonlethal Total-Body Irradiation.Radiation research · 2024Article
- Pharmacology of Aging:Aging biology · 2024Article
- Quantifying the Impact of Co-Housing on Murine Aging Studies.bioRxiv : the preprint server for biology · 2024Article
- Contributions of mouse genetic strain background to age-related phenotypes in physically active HET3 mice.Neurobiology of aging · 2024Article
- Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging.Aging · 2024Article
- The million-molecule challenge: a moonshot project to rapidly advance longevity intervention discovery.GeroScience · 2023Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The field of biogerontology has made great strides towards understanding the biological processes underlying aging, and the time is ripe to look towards applying this knowledge to the pursuit of aging interventions. Identification of safe, inexpensive, and non-invasive interventions that slow the aging process and promote healthy aging could have a significant impact on quality of life and health care expenditures for the aged. While there is a plethora of supplements and interventions on the market that purport to slow aging, the evidence to validate such claims is generally lacking. Here we describe the development of an aging interventions testing program funded by the National Institute on Aging (NIA) to test candidate interventions in a model system. The development of this program highlights the challenges of long-term intervention studies and provides approaches to cope with the stringent requirements of a multi-site testing program.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.