ReviewNeuropsychology review2009
Neuropsychological functioning and antiretroviral treatment in HIV/AIDS: a review.
Review in Neuropsychology review, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 111 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CTNPT 015 - Pilot Project to Implement a Step-wise Investigation That Includes Cerebrospinal (CSF) Analysis as a Standard of Care for HIV+ Individuals With Cognitive Symptoms
Interventions for Symptom Management in Older Patients With HAND
Who cites it
111 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A Meta-Analytic Review of the Effect of Antiretroviral Therapy on Neurocognitive Outcomes in Adults Living with HIV-1 in Low-and Middle-Income Countries.Neuropsychology review · 2022Pooled it
- The Impact of Antiretroviral Therapy on Neurocognitive Outcomes Among People Living with HIV in Low- and Middle-Income Countries (LMICs): A Systematic Review.AIDS and behavior · 2021Pooled it
- Screening tools for HIV-associated neurocognitive disorders among adults living with HIV in sub-Saharan Africa: A scoping review.AAS open research · 2018Pooled it
- Does highly active antiretroviral therapy improve neurocognitive function? A systematic review.Journal of neurovirology · 2010Pooled it
- Pharmacokinetic and pharmacogenetic associations with dolutegravir neuropsychiatric adverse events in an African population.The Journal of antimicrobial chemotherapy · 2022Trial
- The effects of antiretroviral treatment initiation on cognition in HIV-infected individuals with advanced disease in Pune, India.Journal of neurovirology · 2015Trial
- Functional brain abnormalities during finger-tapping in HIV-infected older adults: a magnetoencephalography study.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Trial
- Elevated inflammation in people with HIV is associated with aberrant neural oscillations serving selective attention.Journal of neuroinflammation · 2026Article
- Neuropsychiatric and laboratory outcomes of hepatitis C treatment in an early-treated HIV cohort in Thailand.AIDS research and therapy · 2025Article
- High concordance of human immunodeficiency virus-1 genotypic drug resistance generated from paired cerebrospinal fluid and plasma in antiretroviral therapy -naive or -experienced patients.Frontiers in microbiology · 2025Article
- People with HIV exhibit spectrally distinct patterns of rhythmic cortical activity serving cognitive flexibility.Neurobiology of disease · 2024Article
- Neuropsychiatric and Laboratory Outcomes of Hepatitis C Treatment in an Early-Treated HIV Cohort in Thailand.Research square · 2024Article
- Spontaneous cortical activity is altered in persons with HIV and related to domain-specific cognitive function.Brain communications · 2024Article
- Neuropsychological Correlates of Adherence in Youth with Behaviorally Acquired HIV.AIDS and behavior · 2023Article
- Cognitive impairment in people living with HIV: consensus recommendations for a new approach.Nature reviews. Neurology · 2023Review
- Mitochondrial redox environments predict sensorimotor brain-behavior dynamics in adults with HIV.Brain, behavior, and immunity · 2023Article
- Longitudinal Effects of Combination Antiretroviral Therapy on Cognition and Neuroimaging Biomarkers in Treatment-Naive People With HIV.Neurology · 2022Article
- Neuroinflammation in HIV-associated depression: evidence and future perspectives.Molecular psychiatry · 2022Review
- Altered white matter microstructure and neurocognitive function of HIV-infected patients with low nadir CD4.Journal of neurovirology · 2022Article
- Impact of HIV-infection on human somatosensory processing, spontaneous cortical activity, and cortical thickness: A multimodal neuroimaging approach.Human brain mapping · 2021Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article presents a review of studies that have investigated the neuropsychological effects of antiretroviral treatment (ART) for HIV-1 infection. It provides a brief overview of the era of monotherapy, dual-therapy, and an extended overview of the current era of combination antiretroviral therapy (CART). This review highlights that while CART has had a dramatic effect on the incidence and the severity of HIV-associated neurocognitive disorders (HAND), HAND, in its mild form, still remains prevalent. New causes of this sustained prevalence are poor CNS penetration of some antiretroviral agents, drug resistance, poor adherence, potential neurotoxicity, co-morbidities such as the long-term CART side effects in relation to cardio-vascular disease, and chronic HIV brain infection that may facilitate the expression of new forms of neurodegenerative processes. The review emphasizes the need to address methodological limitations of published studies and the need for large and representative cross-disciplinary longitudinal investigations across the HIV illness span.
Indexed as
Identifiers
19424802What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.