ArticleDigestive diseases and sciences2010
A recent evaluation of empirical cephalosporin treatment and antibiotic resistance of changing bacterial profiles in spontaneous bacterial peritonitis.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Effect of alternative antibiotics in treatment of cefotaxime resistant spontaneous bacterial peritonitis.World journal of gastroenterology · 2013Trial
- Changing Bacterial Profiles and Antibiotic Susceptibility Patterns in Spontaneous Ascites Infection: A Shift in Empiric Combination Antibiotic Therapy?Antibiotics (Basel, Switzerland) · 2025Article
- Understanding the Utility of Automation for Diagnosing Spontaneous Bacterial Peritonitis and Its Variants.Cureus · 2025Article
- Evidence of Significant Ceftriaxone and Quinolone Resistance in Cirrhotics with Spontaneous Bacterial Peritonitis.Digestive diseases and sciences · 2019Article
- An Insight into Antibiotic Resistance to Bacterial Infection in Chronic Liver Disease.Journal of clinical and experimental hepatology · 2017Article
- Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia.World journal of gastroenterology · 2016Observational
- Article
- PREVALENCE OF BACTERIAL RESISTANCE IN HOSPITALIZED CIRRHOTIC PATIENTS IN SOUTHERN BRAZIL: A NEW CHALLENGE.Revista do Instituto de Medicina Tropical de Sao Paulo · 2016Observational
- Multiresistant bacterial infections in liver cirrhosis: Clinical impact and new empirical antibiotic treatment policies.World journal of hepatology · 2015Article
- Patterns of antimicrobial resistance in the causative organisms of spontaneous bacterial peritonitis: a single centre, six-year experience of 1981 samples.International journal of hepatology · 2014Article
- Article
- Spontaneous ascitic fluid infection in liver cirrhosis: bacteriological profile and response to antibiotic therapy.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2013Article
- The new epidemiology of nosocomial bacterial infections in cirrhosis: therapeutical implications.Hepatology international · 2013Article
- Update on the management of cirrhosis - focus on cost-effective preventative strategies.ClinicoEconomics and outcomes research : CEOR · 2013Article
Corrections and comments
- Erratum issuedHusamettin, Erdamar [added]
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this research is to evaluate the recent changes in microorganisms causing spontaneous bacterial peritonitis in cirrhotic patients, antibiotic resistance, and response to empirical cephalosporin therapy. A total of 218 patients with ascites secondary to cirrhosis were enrolled. Parenteral cefotaxime or cefepime was given to patients who had a neutrophil count of 250/mm(3) or more or a positive bacterial culture of ascitic fluid. Antibiotic failure was defined by an absence of clinical improvement and an insufficient decrease in neutrophil count of ascites (<25% of initial value) by the third day of therapy. Of all the patients, 44.6% had culture-negative neutrocytic ascites, 24.8% had spontaneous bacterial peritonitis, and 10.1% had monomicrobial nonneutrocytic bacterascites. Growth in culture was observed in 76 patients (34.9%). The two most common isolated bacteria were Escherichia coli (33.8%) and coagulase-negative Staphylococcus (CoNS; 19.7%). The two cephalosporins were effective against E. coli (82%) and but not against CoNS (44%), while levofloxacin showed reasonable activity against both E. coli (71%) and CoNS (90%) in vitro. We confirmed a recent increased incidence of spontaneous bacterial peritonitis caused by Gram-positive bacteria. Levofloxacin seems to be a good alternative treatment for patients with uncomplicated spontaneous ascites infections.
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