ArticleMolecular imaging and biology
Targeting gelatinases with a near-infrared fluorescent cyclic His-Try-Gly-Phe peptide.
Article in Molecular imaging and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Peptide-Based Strategies for Targeted Tumor Treatment and Imaging.Pharmaceutics · 2021Review
- Imaging Inflammation - From Whole Body Imaging to Cellular Resolution.Frontiers in immunology · 2021Review
- Recent Trends in Cyclic Peptides as Therapeutic Agents and Biochemical Tools.Biomolecules & therapeutics · 2020Review
- A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [Molecules (Basel, Switzerland) · 2019Review
- MMPs and angiogenesis affect the metastatic potential of a human vulvar leiomyosarcoma cell line.Journal of cellular and molecular medicine · 2015Article
- Article
- Systemic delivery of protein nanocages bearing CTT peptides for enhanced imaging of MMP-2 expression in metastatic tumor models.International journal of molecular sciences · 2014Article
- Multi-modality imaging to determine the cellular heterogeneity of nasopharyngeal carcinoma components.Oncotarget · 2014Article
- Multiple target-specific molecular imaging agents detect liver cancer in a preclinical model.Current molecular medicine · 2012Article
- Targeting bladder tumor cells in voided urine of Chinese patients with FITC-CSNRDARRC peptide ligand.OncoTargets and therapy · 2012Article
- Characterization of chemical, radiochemical and optical properties of a dual-labeled MMP-9 targeting peptide.Bioorganic & medicinal chemistry · 2011Article
- Peptides and peptide hormones for molecular imaging and disease diagnosis.Chemical reviews · 2010Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe purpose of the study is to synthesize and characterize near-infrared (NIR) fluorescence imaging probes targeted to gelatinases. PROCEDURES: A phage display-selected cyclic peptide containing the His-Try-Gly-Phe (HWGF) motif was used as the lead compound. Structure-activity relationship analysis was used to identify stable and potent gelatinase inhibitors suitable for NIR imaging applications.
resultsReplacing the S-S bond in cyclic peptide c(CTTHWGFTLC)NH(2) (C1) with an amide bond between the epsilon-amino group of Lys and the side chain of Asp resulted in a significant increase in stability and a fourfold increase in gelatinase inhibition of the resulting peptide, c(KAHWGFTLD)NH(2) (C6). Conjugation of Cy5.5 to C6 led to Cy5.5-C6, which was selectively taken up by MMP-2 expressing human glioma U87 cells. In vivo, selective accumulation of Cy5.5-C6, but not Cy5.5-C1 or a Cy5.5-scrambled peptide conjugate, was visualized in intratibial prostate PC-3 tumors 48 h after their intravenous injection. Moreover, Cy5.5-C6 was readily visualized in orthotopically inoculated U87 brain tumors.
conclusionsCy5.5-C6 may be a useful agent for molecular imaging of gelatinases. The approach of producing stable cyclic peptides through side chain amide linkage should be applicable to other peptide-based imaging agents.
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