SynthesisWorld journal of surgery2009
Systematic review and pooled estimates for the diagnostic accuracy of serological markers for intestinal ischemia.
Synthesis in World journal of surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
86 citing papers in PubMed, 5 syntheses or guidelines pooled it, 264 citations in OpenAlex.
- The Effect of Gut-Training and Feeding-Challenge on Markers of Gastrointestinal Status in Response to Endurance Exercise: A Systematic Literature Review.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Diagnostic accuracy of novel serological biomarkers to detect acute mesenteric ischemia: a systematic review and meta-analysis.Internal and emergency medicine · 2017Pooled it
- Accuracy of using serum D-dimer for diagnosis of acute intestinal ischemia: A meta-analysis.Medicine · 2017Pooled it
- ESTES guidelines: acute mesenteric ischaemia.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2016Guideline
- The Practice Guidelines for Primary Care of Acute Abdomen 2015.Japanese journal of radiology · 2016Guideline
- Effect of remote ischemic preconditioning on postoperative gastrointestinal function in patients undergoing laparoscopic colorectal cancer resection.International journal of colorectal disease · 2023Trial
- Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004.Journal of acquired immune deficiency syndromes (1999) · 2013Trial
- ROS-Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC-H3K27ac-TCF4 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A retrospective analysis of risk factors for intestinal necrosis in pediatric secondary intussusception.BMC pediatrics · 2026Article
- Non-occlusive mesenteric ischemia complicated by ischemic hepatitis presenting as severe lactic acidosis: a case report.Frontiers in medicine · 2026Article
- Computed tomography findings and surgical outcomes in acute mesenteric ischemia: a retrospective single-center cohort study.Frontiers in surgery · 2026Article
- Diagnostic Utility of CT Findings as Indicators for Bowel Resection in Strangulated Small Bowel Obstruction.Journal of clinical medicine · 2025Article
- Immature granulocyte: an early predictor of strangulated adhesive small bowel obstruction.BMC gastroenterology · 2025Article
- Early detection of mesenteric ischemia in critically ill patients following cardiac surgery.Scientific reports · 2025Observational
- Longitudinal analysis of serum intestinal fatty acid-binding protein in a patient with non-occlusive mesenteric ischemia following brachial plexus block-induced hypotension: a case study.Clinical journal of gastroenterology · 2025Article
- Development and validation of a CT-based radiomic nomogram for predicting surgical resection risk in patients with adhesive small bowel obstruction.BMC medical imaging · 2025Article
- Intestinal fatty acid-binding protein (I-FABP) as biomarker of ischemic damage in experimentally induced 12-h small bowel obstruction.Updates in surgery · 2024Article
- Review
- The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntestinal ischemia is a potentially catastrophic abdominal emergency that presents a significant diagnostic challenge in the critical care setting. We performed a systematic review of the literature to define the diagnostic accuracy of serological markers of intestinal ischemia.
methodsObservational studies on the performance of markers of intestinal ischemia were identified within the MEDLINE and EMBASE electronic databases. All studies from which it was possible to derive true positive, false positive, false negative, and true negative results were included. A random-effects model was used to calculate the pooled estimates of diagnostic accuracy.
resultsA total of 20 articles examining 18 different serological markers were identified that met the inclusion criteria. The global measures of test performance (diagnostic odds ratio and area under the summary receiver operating characteristic curve) for markers investigated in three or more studies were D-lactate (10.75 and 0.86, respectively), glutathione S-transferase (GST; 8.82 and 0.87, respectively), intestinal fatty-acid binding protein (i-FABP; 7.62 and 0.78, respectively), and D-dimer (5.77 and 0.53, respectively).
conclusionsThe performance of the currently available serological markers is suboptimal for routine clinical use, but novel markers of intestinal ischemia such as D-lactate, GST, and i-FABP may offer improved diagnostic accuracy. The early diagnosis of intestinal ischemia remains a challenge, and further research is required to identify improved serological markers and to demonstrate their clinical utility in the individual patient.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.