Trial reportEuropean radiology2009
Introduction of an individually optimized protocol for the injection of contrast medium for coronary CT angiography.
Trial report in European radiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Recommendations for accurate CT diagnosis of suspected acute aortic syndrome (AAS)--on behalf of the British Society of Cardiovascular Imaging (BSCI)/British Society of Cardiovascular CT (BSCCT).The British journal of radiology · 2016Guideline
- Personalization of CM Injection Protocols in Coronary Computed Tomographic Angiography (People CT Trial).Contrast media & molecular imaging · 2020Trial
- High-pitch dual-source CT coronary angiography with low volumes of contrast medium.European radiology · 2014Trial
- Revisiting test bolus: a plug-and-play solution for cardiac CTA timing.Pediatric radiology · 2026Article
- Diagnostic accuracy of dual-layer spectral CT for osteolytic vertebral metastases.Skeletal radiology · 2026Article
- Preliminary Evaluation of the Effect of Body Weight on Contrast Enhancement in Coronary CT Angiography: A Fixed Iodine-Dose Protocol.Diagnostics (Basel, Switzerland) · 2026Article
- Artificial Intelligence-Based Prediction of Contrast Medium Doses for Computed Tomography Angiography Using Optimized Clinical Parameter Sets.Methods of information in medicine · 2024Article
- Incidental Indeterminate Renal Lesions: Distinguishing Non-Enhancing from Potential Enhancing Renal Lesions Using Iodine Quantification on Portal Venous Dual-Layer Spectral CT.Journal of personalized medicine · 2023Article
- Optimal Abdominal CT Image Quality in Non-Lean Patients: Customization of CM Injection Protocols and Low-Energy Acquisitions.Diagnostics (Basel, Switzerland) · 2023Article
- A patient- and acquisition-tailored injection approach for improving consistency of CT enhancement towards a target CT value in coronary CT angiography.Journal of applied clinical medical physics · 2023Article
- Investigation of the Utility and Safety of Dynamic Computed Tomography with Vasodilators.Yonago acta medica · 2020Article
- Minimizing individual variations in arterial enhancement on coronary CT angiographs using "contrast enhancement optimizer": a prospective randomized single-center study.European radiology · 2019Article
- Personalized administration of contrast medium with high delivery rate in low tube voltage coronary computed tomography angiography.Quantitative imaging in medicine and surgery · 2019Article
- Individually tailored contrast enhancement in CT pulmonary angiography.The British journal of radiology · 2016Article
- Contrast Enhancement of the Right Ventricle during Coronary CT Angiography--Is It Necessary?PloS one · 2015Article
- Contrast agent bolus tracking with a fixed threshold or a manual fast start for coronary CT angiography.European radiology · 2014Article
- Article
- Shorter delay time reduces interpatient variability in coronary enhancement in coronary CT angiography using the bolus tracking method with 320-row CT.The international journal of cardiovascular imaging · 2013Article
- Ultrafast imaging of the entire chest without ECG synchronisation or beta-blockade: to what extent can we analyse the coronary arteries?Insights into imaging · 2012Article
- Indications, imaging technique, and reading of cardiac computed tomography: survey of clinical practice.European radiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine whether individually tailored protocols for the injection of contrast medium (CM) result in higher and more homogeneous vascular attenuation throughout the coronary arteries at coronary CT angiography compared with conventional injection protocols using fixed injection parameters. Of 120 patients included in the study, 80 patients were randomized into two groups. Group 1 received 80 mL of CM at 6 mL/s. For group 2 injection parameters were individually adjusted to patient weight, the duration of CT data acquisition, and attenuation parameters following a test bolus. In the control group (group 3) the volume of CM was adjusted to the duration of CT data acquisition and injected at 5 mL/s. Attenuation was measured in the proximal, middle, and distal right coronary artery (RCA), in the proximal and middle left anterior descending artery (LAD), and in cranial and caudal sections of both ventricles. Patient parameters, scan delay, and scan duration did not differ significantly between the groups. Mean CM volume was 82.5 mL (flow rate 5.1 mL/s) in group 2 and 73.5 mL in group 3. Attenuation in both RCA and LAD was significantly higher for group 2 vs. group 3 (RCA: 414.9 + or - 49.9)-396.1(+ or - 52.1) HU vs. 366.0(+ or - 64.3)-341.6(+ or - 72.5) HU; LAD: 398.9(+ or - 48.6)-364.6(+ or - 44.6) HU vs. 356.3(+ or - 69.5)-323.0(+ or - 67.2) HU). For group 1 vs. group 2 only attenuation in the distal RCA differed significantly: 396.1(+ or - 52.1) vs. 370.7(+ or - 70.5) HU. Individually tailored CM injection protocols yield higher attenuation, especially in the distal segments of the coronary vessels, compared with injection protocols using fixed injection parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.