ArticlePloS one2009
CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Navigating the landscape of the unfolded protein response in CD8Frontiers in immunology · 2024Review
- Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma.Journal of experimental & clinical cancer research : CR · 2021Article
- Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex.The Journal of clinical investigation · 2021Article
- Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8Nature immunology · 2020Article
- Stress Adapted Mollusca and Nematoda Exhibit Convergently Expanded Hsp70 and AIG1 Gene Families.Journal of molecular evolution · 2019Article
- Stressed: The Unfolded Protein Response in T Cell Development, Activation, and Function.International journal of molecular sciences · 2019Review
- The Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities.Frontiers in immunology · 2019Review
- Endoplasmic reticulum stress regulates tumor growth and anti-tumor immunity: a promising opportunity for cancer immunotherapy.Cancer immunology, immunotherapy : CII · 2017Review
- GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes.Frontiers in immunology · 2017Article
- DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells.The Journal of biological chemistry · 2015Article
- An improved high-throughput screening assay for tunicamycin sensitivity in Arabidopsis seedlings.Frontiers in plant science · 2015Article
- Quercetin ameliorates tunicamycin-induced endoplasmic reticulum stress in endothelial cells.Cell proliferation · 2014Article
- Activated macrophage-like synoviocytes are resistant to endoplasmic reticulum stress-induced apoptosis in antigen-induced arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Is there a common upstream link for autophagic and apoptotic cell death in human high-grade gliomas?Neuro-oncology · 2011Article
- Protective Mechanism of KIOM-4 in Streptozotocin-Induced Pancreatic β-Cells Damage Is Involved in the Inhibition of Endoplasmic Reticulum Stress.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein.Self/nonself · 2010Article
- Simvastatin decreases endothelial progenitor cell apoptosis in the kidney of hypertensive hypercholesterolemic pigs.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress.Arthritis research & therapy · 2010Article
- GIMAP Proteins in T-Lymphocytes.Journal of signal transduction · 2010Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Gimap5 (GTPase of the immunity-associated protein 5) has been linked to the regulation of T cell survival, and polymorphisms in the human GIMAP5 gene associate with autoimmune disorders. The BioBreeding diabetes-prone (BBDP) rat has a mutation in the Gimap5 gene that leads to spontaneous apoptosis of peripheral T cells by an unknown mechanism. Because Gimap5 localizes to the endoplasmic reticulum (ER), we hypothesized that absence of functional Gimap5 protein initiates T cell death through disruptions in ER homeostasis. We observed increases in ER stress-associated chaperones in T cells but not thymocytes or B cells from Gimap5(-/-) BBDP rats. We then discovered that ER stress-induced apoptotic signaling through C/EBP-homologous protein (CHOP) occurs in Gimap5(-/-) T cells. Knockdown of CHOP by siRNA protected Gimap5(-/-) T cells from ER stress-induced apoptosis, thereby identifying a role for this cellular pathway in the T cell lymphopenia of the BBDP rat. These findings indicate a direct relationship between Gimap5 and the maintenance of ER homeostasis in the survival of T cells.
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