ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2009
Contrast-enhanced ultrasonography for real-time monitoring of interstitial laser thermal therapy in the focal treatment of prostate cancer.
Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- The State-of-the-Art and Perspectives of Laser Ablation for Tumor Treatment.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Review
- MR Imaging in Real Time Guiding of Therapies in Prostate Cancer.Life (Basel, Switzerland) · 2022Review
- The Design and Rationale of a Multicentre Randomised Controlled Trial Comparing Transperineal Percutaneous Laser Ablation With Transurethral Resection of the Prostate for Treating Benign Prostatic Hyperplasia.Frontiers in surgery · 2021Article
- Focal Laser Ablation of Prostate Cancer: Results in 120 Patients with Low- to Intermediate-Risk Disease.Journal of vascular and interventional radiology : JVIR · 2019Article
- The prostate cancer focal therapy.Gland surgery · 2018Review
- Multiparametric dynamic contrast-enhanced ultrasound imaging of prostate cancer.European radiology · 2017Article
- Laser Ablation for Cancer: Past, Present and Future.Journal of functional biomaterials · 2017Review
- Robotic System for MRI-guided Focal Laser Ablation in the Prostate.IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division · 2017Article
- Diagnostic and prognostic values of contrast-enhanced ultrasound in breast cancer: a retrospective study.OncoTargets and therapy · 2017Article
- Vascular targeted photochemotherapy using padoporfin and padeliporfin as a method of the focal treatment of localised prostate cancer - clinician's insight.World journal of methodology · 2016Review
- Focal laser ablation for localized prostate cancer: principles, clinical trials, and our initial experience.Reviews in urology · 2014Article
- Focal laser ablation of prostate cancer: definition, needs, and future.Advances in urology · 2012Article
- Pros and cons of focal therapy for localised prostate cancer.Prostate cancer · 2011Article
- Image guidance for focal therapy of prostate cancer.World journal of urology · 2010Review
- Photodynamic therapy for focal ablation of the prostate.World journal of urology · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe report a case study of the application of contrast-enhanced ultrasonography (CEUS) for intraoperative monitoring of thermal ablation of a single focus of prostate cancer.
methodsA patient presented with biopsy-proven, solitary-focus, low-risk prostate cancer and was recruited into a clinical trial of interstitial laser thermal focal therapy. Multiparametric magnetic resonance imaging (MRI) was used to locate the single dominant focus, and photothermal ablation was performed at the tumour site under the guidance of transrectal ultrasonography. Transrectal CEUS using systemic bolus injections of the intravascular contrast agent Definity was performed immediately before, several times during and on completion of therapy. Lesions observed on CEUS were compared with treatment effect as measured by tissue devascularization on 1-week gadolinium (Gd)-enhanced MRI.
resultsBaseline images showed CEUS contrast-agent signal throughout the prostate. During and after treatment, large hypocontrast regions were observed surrounding the treatment fibres, indicating the presence of an avascular lesion resulting from photothermal therapy. Lesion size was found to increase during the delivery of thermal energy. Lesion size measured using CEUS (16 x 11 mm) was similar to the 7-day lesion measured using Gd-enhanced T(1)-weighted MRI.
conclusionFocal therapy for prostate cancer requires both complete treatment of the dominant tumour focus and minimal morbidity. The application of CEUS during therapy appears to provide an excellent measure of the actual treatment effect. Hence, it can be used to ensure that the therapy encompasses the whole target but does not extend to surrounding critical structures. Future clinical studies are planned with comparisons of intraoperative CEUS to Gd-enhanced MRI at 7 days and whole-mount pathology samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.