Evidence map›Paper›PMID 19424011›Full record

ArticleTransplantation2009

Mechanisms of transplantation tolerance in animals and humans.

Megan Sykes

Open access · greenAbstract read
In one paragraph

Article in Transplantation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Hematopoietic stem cells and solid organ transplantation.Transplantation reviews (Orlando, Fla.) · 2016
    Review
  6. Macrochimerism in Intestinal Transplantation: Association With Lower Rejection Rates and Multivisceral Transplants, Without GVHD.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2015
    Article
  7. Tolerance after solid organ and hematopoietic cell transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Megan SykesBone Marrow Transplantation Section, Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA. megan.sykes@tbrc.mgh.harvard.edu
Harvard University · US

Funding

XENOGENIC TOLERANCE IN MICEP01HL018646 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 1985 to 2019
$37.5M
STATISTICAL COREP01CA111519 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PREFFER, FREDERIC IRA · 2006 to 2010
$9.3M
MIXED CHIMERISM AS AN APPROACH TO TRANSPLANT TOLERANCER01HL049915 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SYKES, MEGAN · 1993 to 2010
$3.9M
SEPARATION OF GVH AND GVL IN MOUSE MODELSR01CA079989 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SYKES, MEGAN · 2000 to 2008
$2.2M
NCI NIH HHS P01 CA111519NCI NIH HHS R01 CA079989NHLBI NIH HHS P01 HL018646NHLBI NIH HHS P01 HL18646NHLBI NIH HHS R01 HL049915NHLBI NIH HHS R01 HL49915
6 · The paper itself

Abstract

Donor-specific immune tolerance would avoid the toxicities of chronic immunosuppressive therapies while preventing graft rejection. Hematopoietic cell transplantation has shown preliminary success for intentional tolerance induction in pilot clinical trials. The mechanisms of tolerance in these trials and the animal studies leading up to them are discussed.

Indexed as

AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesGraft vs Host DiseaseHematologic NeoplasmsHematopoiesisHematopoietic Stem Cell TransplantationHumansImmunosuppression TherapyLymphocyte SubsetsMiceModels, AnimalPilot ProjectsT-LymphocytesTransplantation ChimeraTransplantation, Homologous

Identifiers

PMID19424011
PMCPMC2720021
OpenAlexW2076505435

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.